简介：目的:探讨Q开关Nd:YAG激光后囊膜切开术治疗后囊膜混浊的疗效及安全性.方法:回顾性分析行Q开关Nd:YAG激光后囊膜切开术后囊膜混浊患者165例(193眼),记录手术前后视力、眼压及并发症,并进行统计学分析.结果:①后囊膜一次性切开成功率为100%,所用激光脉冲数平均24±21.7次,激光总能量4～451mJ;②91.2%(176眼)视力较术前提高;③59.6%(115眼)出现一过性眼压升高;手术前后眼压变化与是否植入人工晶状体、所用激光脉冲数以及白内障手术与后囊膜切开术间隔时间有关;④19.3%(32眼)出现人工晶状体损伤.结论:Q开关Nd:YAG激光后囊膜切开术治疗后囊膜混浊安全、有效,但应严格掌握适应证,并合理选择激光参数.

简介：AIM:Tostudytheassociationsbetweenlysyloxidaselike1(LOXL1)polymorphismsandprimaryopenangleglaucoma(POAG)remaininconsistent.Inthisstudy,wehaveperformedameta-analysistoinvestigatetheassociationofLOXL1polymorphismswithPOAGrisk.METHODS:PublishedliteraturefromPubMedandotherdatabaseswereretrieved.AllstudiesevaluatingtheassociationbetweenLOXL1polymorphisms(rs2165241,rs1048661,rs3825942)andPOAGriskwereincluded.Pooledoddsratio(OR)and95%confidenceinterval(CI)werecalculatedusingrandom-orfixed-effectsmodel.RESULTS:Twelvestudieswereidentifiedaseligiblearticles,withthirteen(2098casesand16473controls),thirteen(1795casesand2916controls)andsixteenpopulationcohorts(2456casesand2846controls)fortheassociationofrs2165241,rs1048661andrs3825942withPOAGriskrespectively.OverallanalysesshowednoassociationbetweeneachLOXL1polymorphismandPOAGrisk,andthenegativeassociationswereremainedwhenthesubjectswerestratifiedasCaucasianandAsian.Theheterozygoteofrs2165241wasassociatedwithreducedPOAGriskinhospital-basedpopulations(TCvsCC:OR,0.79,95%CI:0.63-0.99),andrs1048661wasassociatedwithincreasedPOAGriskinhospitalbasedpopulationsinadominantmodel(TTvsCC+CT:OR,1.23,95%CI:1.01-1.50);however,theseassociationswerenotfoundinpopulation-basedsubjects.CONCLUSION:Thismeta-analysissuggeststhatLOXL1polymorphismsarenotassociatedwithPOAGrisk.Giventhelimitedsamplesize,theassociationsofLOXL1polymorphismswithPOAGriskinhospital-basedpopulationsawaitfurtherinvestigation.

简介：目的：通过对Q值调整非球面切削与标准化LASIK术后视觉质量的观察来分析Q值引导个性化切削技术的临床效果。方法：对2008-01/05等效球镜低于-12.00D的46例88眼进行非球面切削或标准化LASIK术后进行随访,按术前屈光度数将其分为A组（〈-6.00D）和B组（-6.00～-12.00D）两组,对比各组非球面切削与标准化LASIK术后1mo裸眼视力、Q值、夜间眩光、夜间视物质量及满意率（后3者采取问卷调查）。结果：A、B组内非球面切削与标准化LASIK术后裸眼视力差异无统计学意义（t=1.18,P〉0.05;t=0.62,P〉0.05）;A、B组内非球面切削与标准化LASIK术后Q值差异无统计学意义（t=-0.93,P〉0.05;t=-0.372,P〉0.05）;A组内非球面切削与标准化LASIK术后眩光、夜间视物质量差异无统计学意义（眩光：χ^2=2.397,P＆gt;0.05;夜间视物质量：χ2=1.263,P〉0.05）;B组内非球面切削与标准化LASIK术后眩光、夜间视物质量差异有统计学意义（眩光：χ^2=10.85,P〈0.01;夜间视物质量：χ^2=10.85,P〈0.01）;术后效果满意率达到98％。结论：非球面切削能明显改善-6．00D以上的术后主观视觉质量。