简介：【摘要】目的：观察比较Q-开关倍频Nd:YAG激光和光子嫩肤仪治疗雀斑的疗效。方法：将 2019年6月至2020年6月我院接收的270例雀斑病人进行研究，根据随机抽签法进行分组，将其分为实验组和参照组，每组各135例。参照组病人选择使用光子嫩肤仪进行治疗，实验组则是使用Q-开关倍频Nd:YAG激光仪进行治疗，比较两组病人的治疗效果以及不良反应的情况。结果：实验组病人与参与组的治疗效果无明显差异，（P＞0.05）；但实验组病人的不良反应情况则是优于参照组,差异较大（P＜0.05）。结论：从临床效果上看来Q-开关倍频Nd:YAG激光与光子嫩肤仪治疗雀斑的效果虽然无明显差异，但是治疗效果的保存的却是Q-开关倍频Nd:YAG激光治疗方法会明显的增长。

简介：AbstractThe chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system. Abnormal expression of CMTM is associated with the development of various diseases. This article summarizes the relevant research on the role of the CMTM family in immune disorders. This information will increase our understanding of pathogenesis and identify promising targets for the diagnosis and treatment of autoimmune diseases. The CMTM family is highly expressed in peripheral blood mononuclear cells. CKLF1 may be involved in the development of arthritis through its interaction with C-C chemokine receptor 4. CKLF1 is associated with the pathogenesis of lupus nephritis and psoriasis. Both CMTM4 and CMTM5 are associated with the pathogenesis of systemic lupus erythematosus. CMTM1, CMTM2, CMTM3, and CMTM6 play a role in rheumatoid arthritis, systemic sclerosis, Sjögren syndrome, and anti-phospholipid syndrome, respectively. The CMTM family has been implicated in various autoimmune diseases. Further research on the mechanism of the action of CMTM family members may lead to the development of new treatment strategies for autoimmune diseases.

简介：<正>Q:请问瘦人想练得壮些,吃东西注意些什么?A:蛋白质是肌肉增长最重要的营养源,健美训练者蛋白质的摄人应以非脂或低脂食品为主,如脱脂牛奶、蛋清、鱼、去皮家禽、牛排等,瘦人可以适当的增加高热量的碳水化合物和脂肪的摄入。只有摄入的能量大于消耗的能量,人才能变壮。因此,消瘦者的膳食调配一定要合理、多样,不可偏食。平时除食用富含动物性蛋白质的肉、蛋、禽类等,碳水化合物也是重要部分,还要适当多吃一些豆制品及赤豆、百合、蔬菜、瓜果等。蛋白质,碳水化合物,脂肪三种主要营养素的比例应为:40%:40%:20%只要饮食营养全面,利于消化吸收,再加上适当的健美锻炼,就能在较短时间内变得健壮起来。

简介：思源：我今年30岁了，还没有真正谈过一场恋爱。对于与异性交往，我似乎有点卡在瓶颈了。家人一直逼婚，真不知道该怎么办。

简介：Q：什么是慢性胃炎？A：指不同病因引起的胃粘膜慢性炎症，即胃粘膜出现充血、水肿、炎性细胞浸润以及腺体萎缩。慢性胃炎不是我们平时意义上的炎症（即出现红、肿、热、痛、发烧），也不是胃的外表面有问题，而是胃的最里面一层即胃粘膜的炎症性病变。它是一个病理学概念，严格地讲应该称之为“慢性胃粘膜炎症”。

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简介：AbstractSchnitzler syndrome is a rare disease of adult-onset with main features including chronic urticarial rash, recurrent fever, arthralgia or arthritis, monoclonal gammopathy of undetermined significance (MGUS), and marked systemic inflammation. Schnitzler syndrome is often underdiagnosed. Patients with Schnitzler syndrome may present to dermatologists and allergists for urticaria, hematologists for MGUS, or rheumatologists for arthritis. It is important to recognize Schnitzler syndrome for its remarkable response to interleukin (IL)-1 blockade. Besides, many cases of Schnitzler-like syndromes do not meet the diagnostic criteria of classical Schnitzler syndrome but display excellent response to IL-1 inhibitors. The overly produced IL-1 is the result of a somatic mosaic gain of function mutation of NLRP3 (nucleotide-binding oligomerization domain [NOD]-like receptor [NLR] family pyrin domain containing 3) gene in some patients with Schnitzler-like syndromes. Inflammasome activation is evident in patients with classical Schnitzler syndrome although no NLRP3 gene mutation is identified. Collectively, Schnitzler syndrome and Schnitzler-like syndromes represent a spectrum of IL-1 mediated adult-onset autoinflammatory diseases.

简介：AbstractAntiphospholipid syndrome (APS) is a systemic autoimmune disease defined by thrombotic or obstetrical events and persistent antiphospholipid antibodies (aPLs). Chemokine-like factor-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system and may closely related to APS. This review aimed to systematically summarize the possible effects of CMTM on APS. Publications were collected from PubMed and Web of Science databases up to August 2020. CKLF, CKLFSF, CMTM, antiphospholipid syndrome, immune cells, and immune molecules were used as search criteria. Immune cells, including neutrophil, dendritic cells (DCs), T-cells, B-cells, and inflammatory cytokines, play an important role in the development of APS. Chemokine-like factor 1 (CKLF1) has a chemotactic effect on many cells and can affect the expression of inflammatory cytokines and adhesion molecules through the nuclear factor-kB (NF-kB) pathway or mitogen-activated protein kinase (MARK) pathway. CKLF1 can participate in the maturation of DCs, T lymphocyte activation, and the activation of neutrophils through the MAPK pathway. CMTM1 may act on Annexin A2 by regulating Ca2+ signaling. CMTM2 and CMTM6 are up-regulated in neutrophils of APS patients. Some CMTM family members influence the activation and accumulation of platelets. CMTM3 and CMTM7 are binding partners of B-cell linker protein (BLNK), thereby linking B cell receptor (BCR) and activating BLNK-mediated signal transduction in B cells. Moreover, CMTM3 and CMTM7 can act on DCs and B-1a cell development, respectively. CMTM may have potential effects on the development of APS by acting on immune cells and immune molecules. Thus, CMTM may act as a novel prognostic factor or immunomodulatory treatment option of APS.

简介：<正>中国健美先生王树立四届中国健美锦标赛冠军四届中国健美锦标赛最佳表演金奖汉城亚州健美锦标赛第三名中国体育行业职业技能鉴定考评员

简介：Q如何检视自已有没有肝胆结石?A肝脏因为本身没有神经末梢系统,对于早期病变缺乏疼痛知觉而表现的浑然不觉。胆囊因位于肝脏下缘,所以有些疾病在早期是感受不到症状的。

简介：<正>您好,请问我14岁,身高164厘米,体重55公斤,腰围61厘米。开始要减脂能不能早餐2个蒸鸡蛋,2片全麦面包,250毫升低脂豆奶,5颗杏仁。午餐4片全麦面包,晚餐150-200克土豆,200克西兰花和100克牛柳。还会喝绿茶,因为6月上期说过食粗粮会导致青少年发育不良。我这样吃不知道会不会造成发育不良。谢谢!

简介：Q：水对人体为什么那么重要？A：水对人体十分重要，无论是营养素的消化、吸收、运输和代谢，还是废物的排出，或是生理功能及体温的调节等等，都离不开水。如果没有水，新陈代谢活动就不能进行。水占人体体重的70％，没有水，生命将终止。

简介：Q我是名公司的前台，每天都要带妆上班，我比较喜欢稍显浓重的妆容。可是一到夏天，我就很容易莫名其妙的在嘴唇附近红肿胀痒，眼睛也会不知原因的红痒不舒服。我去医院检查，也没有查出过敏源。同事说我这可能跟化妆有关，我想了解下，夏天化妆真的容易引起过敏的症状吗？

简介：<正>第三个星期:经过延续两个星期的练习当前,训练者曾经关于训练举措有一定的理解和熟悉。在这个礼拜里会改动一些原有方案中的训练举措,使训练者掌握更多的训练举措,练就愈加片面均衡的体型。本周开端肌肉的力量和心肺功用都有所进步了,还是要提示一下大家,别忘了文章扫尾提到的不要随便添加训练负荷。同时这周开端延迟性疼痛症状也会

简介：Q：我最近身体比较虚弱，想去抓两副中药来补补。请问夏天吃中药有什么讲究吗？A：夏天进补中药是有一定禁忌的。1、中药不宜过度温热。温热药用来治疗寒症，夏季大量使用常会出现发热、出血、疮疡等病变。即使必须使用，也只能减少剂量．缩短疗程。2、不宜过度发汗。夏季人体易出汗，此时再服大量发汗药，势必大汗淋漓，导致体内水分失衡，甚至出现休克等危重症候。3、不宜过度滋补。滋补药不易吸收，只有消化功能完善的人才能使用，否则会出现腹胀、不思饮食等现象。而人在夏季，胃肠功能低，故不宜使用，再忌过度滋补。

简介：Inthepresentstudywehavefoundthatproto-oncogenec-fosproteincanexpressinthenoradrenergicneuronsofrathindbrainfollowingperipheralelectricalstimulation.Ratsweregivenperipheralelectricalstimulationviathinstainlesssteelpinsinsertedintothepointsnearkneejoint(S36)andanklejoint(Sp6)whichmimicthemanipulationofelectroacupuncture(EA)performedinhumans.Animalswereperfusedfordoublestainingimmunohistochemistry2haftertheterminationofEA.InratssubjectedtoEAstimulationFos-likeproteinwasfoundinthetyrosinehydroxylase(TH)-likeimmunoreactiveneuronsinrathindbrain.TheFosandTHcoex-istingneuronsweredistributedinthelocuscoeruleus,solitarytractnucleus,ventrolateralmedul-la,periaqeductalgray,aswellassuperiorcolliculus.ThepercentageofthecoexistingneuronscomparedwiththetotalnumberofneuronscontainingFos-likeproteininthesenucleirangedfrom6%to32%.Theresultssuggestthatthenoradrenergicneuronsintheseregionsmaybeac-tivtedbyacupuncturestimulation.

简介：摘要生物类似药具有与参照药相似的质量、疗效和安全性，同时具有价格优势，对实现我国居民用药的更高可及性具有非常重要的意义。为加深对生物类似药这一新兴概念的正确认识，规范我国生物类似药的临床用药，共识专家组参考国内外相关循证医学证据，结合临床用药体会，经充分讨论沟通，达成以下共识：（1）生物类似药与参照药疗效等同、安全性相似，临床上可以替代使用；（2）根据"适应证外推"原则，生物类似药可获得参照药具有相同作用机制的其他所有适应证，而且对外推适应证的疗效和安全性与参照药相似；（3）对于正在接受治疗的患者，临床医生可根据患者情况，决定是否由使用参照药转换成使用生物类似药。

简介：大脑是心理活动的基础，心理活动是大脑的高级功能。在心理门诊工作中，应注意一些类似心理障碍的特殊类型癫痫的来访者，以免误诊。笔者把2000年9月-2003年9月遇到的类似心理障碍的特殊类型癫痫(共9例)介绍如下。

简介：TheSOD-likeactivityoffiveCu(Ⅱ)complexes[Cu(HSal)_2·EtOH,Cu(Gly)_2,Cu(Lys)_2,Cu(His)_2,Cu(Try)_2]havebeenstudiedbyusingcytochromeCmethod,aswellaschemilumine-scenceandESRtechnique.Thefoursurfactants(CTAB,SDS,TritonX-100andTween20)werepurifiedandtheircriticalmiceileconcentration(CMC)inphosphatebuffer(pH=7.4)wasmea-sured.TheeffectsoffoursurfactantsonO_2~-havebeeninvestigated.Theco-operativeeffectsof