摘要Functional dyspepsia (FD) and gastroparesis are two common functional gastrointestinal diseases, affecting millions of people in both China and around the world. However, treatment options are limited and difficult due to multiple factors involved in their pathophysiologies. Therefore it is critically important to assess and understand pathophysiologies of these diseases before a treatment is given. In this minireview we provide updates on recent development in the pathophysiologies and treatments of FD and gastroparesis. In addition to common abnormalities in gastric accommodation, antral hypomotility and visceral hypersensitivity, FD has recently been reported to display a number of impairment in duodenal functions, such as low-grade inflammation and increased permeability. For gastroparesis, macrophages have recently been reported to play an important role in its pathophysiology. A brief overview on the assessment of pathophysiologies of FD and gastroparesis is also provided; pros and cons of clinically available methodologies as well as emerging methods are discussed. Finally, available treatment options for FD and gastroparesis are presented in this minireview, including authors′ opinions on the advantages and disadvantages of each therapy. Potential novel therapies for FD and gastroparesis, especially those associated with Traditional Chinese Medicine, are also introduced and discussed.
