简介：影片《幸福终点站》(TheTerminal)是一部由大牌导演StevenSpielberg和著名明星TomHanks，CatherineZeta—Jones联袂打造的浪漫喜剧片。影片是对一个真实事件的浪漫演绎：16年前，一个名叫MerhanKarimiNasseri的伊朗人被困法国戴高乐机场，并由此开始了漫长的机场滞留生活。他丢掉了身份，无家可归，

简介：TheoriginallocationsandrelationshipsoffourplateswithinthemainlandofChinafrom800to600MaduringtheterminalPrecambrianwerereconstructedbasedonthepalaeomagneticandgeologicaldata.TheTarim,YangtzeandCathaysianplateswereoncelinked(in800-700Ma)andlocatedinthesamelow-latitudezoneofthenorthernhemisphere.Butlater,in700-600Ma,theTarimplatewasseparatedfromtheYangtze-Cathaysianplate.TheSino-KoreanplatewasalwaysfarawayfromtheYangtzeplate,bothbeingseparatedbyoceaniccrust,andlayinthehigh-latitudezoneofthenorthernhemisphere.Theabove-mentionedpalaeogeographicframeworkdirectlyledtocompletedifferencesinrespecttodistributionoflow-latitudeglaciation,sedimentaryfacies,palaeoclimate,palaeobiogeographyandstratigraphicsectionsbetweentheNorthandSouthChinadomainsduringtheterminalPrecambrian.

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简介：TheNetAcetmethodhasbeendevelopedtomakepredictionsofN-terminalacetylationsites,butmoreinformationofthedatasetcouldbeutilizedtoimprovetheperformanceofthemodel.Byemployinganewwaytoextractpatternsfromsequencesandusingasamplebalancingmechanism,weobtainedacorrelationcoefficientof0.85,andasensitivityof93%onanindependentmammaliandataset.Awebserverutilizingthismethodhasbeenconstructedandisavailableathttp://166.111.24.5/acetylation.html.

简介：Alongwiththeincreasinglyurgentmanagementneedsofintranetterminalsinhospital,andlargescaleddeploymentofterminalmanagementsystem,terminalaccesscontrolhasbecomeoneofthestandardfunctionsofterminalmanagement.Thispapermainlyaimsatsomesimpleresearchforthesystemconstructionofhospitalintranetterminalaccesscontrol.

简介：Asemi-analyticalmethodintimedomainispresentedforanalysisofthetransientresponseofnonuniformtransmissionlines.Inthismethod,thetelegraphequationsintimedomainisdifferencedinspacedomainfirst,andistransformedintoasetoffirst-orderdifferentialequationsofvoltageandcurrentwithrespecttotime.Byintegratingthesedifferentialequationswithrespecttotime,andprecisecomputation,thesolutionofthesedifferentialequationscanbeobtained.Thismethodcansolvethetransientresponseofvariouskindsoftransmissionlineswitharbitraryterminalnetworks.Particularly,itcananalyzethenonuniformlineswithinitialconditions,forwhichthereisnoexistingeffectivemethodtoanalyzethetimeresponsesofar.Theresultsobtainedwiththismethodarestableandaccurate.Twoexamplesaregiventoillustratetheapplicationofthismethod.

简介：Inordertoprobethedeathreasonofterminalbudsandcarryouttrunkextensionbyusinglateralbuds,thetemperaturecharacteristicsofdormancydevelopmentofterminalandlateralbudsinPaulowniatomentosaxp.fortunei33wereinvestigatedbyraisingcuttingbranchesondifferentdateat25℃and15℃.Theresultswereasfollows:①Thedeathreasonofterminalbudsandthefirstpairoflateralbudswasitselfecologicaladaptingstrategy,nottheinjuryofearlyfrostandfreezing;②Thelateralbuds2,3and4hadobtainedthefeatureofwinterdormancy,andcouldsurvivefromcoldwinter,andwidenitspossibletemperaturerangeofsproutingtolowertemperaturebyexperiencingwinterchilling;③Thelateralbuds2,3and4couldsproutatthesametimeinspring,butitwasdifficulttosproutforotherlateralbuds;④Thesproutingofupperlateralbudscouldrestrictthesproutingoflowerlateralbudsat25℃,butnotat15℃.

简介：Thispaperinvestigatestheoreticallytheelectronictransmissionspectraofthethreeterminalpyrenemolecularbridgeandthequantumcurrentdistributiononeachbondbythetight-bindingmodelbasedonnonequilibriumGreen'sfunctionandthequantumcurrentdensityapproach,inwhichoneπmolecularorbitalistakenintoaccountpercarbonatomwhentheenergylevelsandHOMO-LUMOgapareobtained.Thetransmissionspectrashowthattheelectronictransmissionofthethreeterminalpyrenemolecularbridgedependsobviouslyontheincidentelectronicenergyandthepyreneeigenenergy.Thesymmetricalandoscillationpropertiesofthetransmissionspectraareillustrated.Anovelplus-minusenergyswitchingfunctionisfound.Thequantumcurrentdistributionshowsthattheloopcurrentsinsidethepyreneareinduced,andsomebondcurrentsaremuchlargerthantheinputandtheoutputcurrents.Thereasonswhytheloopcurrentsandthelargerbondcurrentsareinducedarethephasedifferenceoftheatomicorbitsandthedegeneracyofthemolecularorbits.ThecalculationsillustratethatthequantumcurrentdistributionsareingoodagreementwithKirchhoffquantumcurrentconservationlaw.

简介：Kr眉p像像素的因素8(KLF8)抄写因素在房间周期前进起一个关键作用，oncogenic转变，对间充质的转变和侵略上皮。然而，它的原子本地化信号(NLS)没被识别。有另外的KLFmonopartiteNLS(mNLS)和C2H2锌手指(ZF)的KLF8份额，哪个被显示了是为一些另外的KLF的NLS。在这份报告，用指导PCR的mutagenesis和immunofluorescent显微镜学，我们显示出mNLSs，任何单个ZF的删除，或变化的那混乱Zn2+有约束力或联系DNA主题没影响KLF8的原子本地化。删除>然而，从C终点的1.5ZF引起了KLF8的细胞质的累积。令人惊讶地，氨基酸(aa)的删除151-200区域几乎从原子核消除了KLF8。有PKC禁止者的S165A，K171E或K171R变化，或处理导致了部分细胞质的累积。Co-immunoprecipitation证明KLF8与importin-交往了，这个相互作用要求了ZF主题。aa1-150或201-261区域的删除独自没改变原子本地化。BrdU加入和cyclinD1倡导者酶试金作为野类型的KLF8证明在原子本地化的KLF8异种有缺陷者不能支持DNA合成或cyclinD1倡导者激活。一起拿，这些结果建议KLF8有二NLS，一包围S165和K171并且另外的是二双人脚踏车ZF，它为KLF8原子本地化和它的细胞的功能的规定是批评的。

简介：Humanrhodopsinkinase(RK)andacarboxylterminus-truncatedmutantRKlackingthelast59aminoacids(RKC)wereexpressedinhumanembryonickidney293cellstoinvestigatetheroleofthecarboxylterminusofRKinrecognitionandphosphorylationofrhodopsin.RKC,likethewild-typeRK,wasdetectedinbothplasmamembranesandcytosolicfractions.TheCterminaltruncatedrhodopsinkinasewasunabletophosphorylatephoto-activatedrhodopsin,butpossesseskinaseactivitysimilartothewild-typeRKinphosphorylationofsmallpeptidesubstrate.ItsuggeststhatthetruncationdidnotdisturbthegrossstructuresofRKcatalyticdomain.OurresultsalsoshowthatRKCfailedtotranslocatetophoto-activatedrodoutsegments.Takentogether,ourstudydemonstratethecarboxylterminusofRKisrequiredforphosphorylationofphoto-activatedrhodopsinandstronglyindicatethatcarboxyl-terminusofRKmaybeinvolvedininteractionwithphoto-activatedrhodopsin.

简介：Recurrenteventsdatawithaterminalevent(e.g.death)oftenariseinclinicalandobservationalstudies.Mostofexistingmodelsassumemultiplicativecovariateeffectsandmodeltheconditionalrecurrenteventrategivensurvival.Inthisarticle,weproposeageneraladditive-multiplicativeratesmodelforrecurrenteventdatainthepresenceofaterminalevent,wheretheterminaleventstopthefurtheroccurrenceofrecurrentevents.Basedontheestimatingequationapproachandtheinverseprobabilityweightingtechnique,weproposetwoproceduresforestimatingtheregressionparametersandthebaselinemeanfunction.Theasymptoticpropertiesoftheresultingestimatorsareestablished.Inaddition,somegraphicalandnumericalproceduresarepresentedformodelchecking.Thefinite-samplebehavioroftheproposedmethodsisexaminedthroughsimulationstudies,andanapplicationtoabladdercancerstudyisalsoillustrated.

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简介：AbstractThetemporaldevelopmentofasinglemodeRayleigh-Taylorinstabilityconsistsofthreestages:thelinear,freefallandterminalvelocityregimes.Thepurposeofthispaperistoreportonnewphenomenaobservedintheapproachtoterminalvelocity.Ournumericalstudyshowsanunexpectednonuniformapproachtoterminalvelocity.Thenonuniformityappliesespeciallytothespikes,whicharefingersofheavyfluidfallingintothelightfluid,butitalsoappliestotherisingbubblesoflightfluid.ForspikesespeciallyourresultscallintoquestionthemeaningfulnessofaterminalvelocityformoderatevaluesoftheAtwoodnumberA.Afterashorttimeperiodofpseudo-terminalplateau,thespikevelocityincreasestoasignificantlyhighermaximum,followedbyadecrease.Thisphenomenaappearstobeduetoaslowevolutionintheshapeofthespikeandbubble.Wefindarelationbetweenthespike(bubble)accelerationandthetipcurvature.Incorrelationwithanincreaseinthespikevelocity,th

简介：Thec-JunN-terminalkinases(JNKs)areclassicstress-activatedproteinkinases.ManycellularstresseshavebeenshowntostimulateJNKactivation.Inthisreview,wefocusonribotoxicstressesbasedontheirmultiplebiologicalpotenciesincludinganti-HIV-1activity.Someofthefunctionsofribotoxinsandthesignalingtransductionpathwaythatmediatedarementioned.Differentfromotherstimulators,ribotoxicstressesactonspecialmotifsof28SrRNAintranslationallyactivemammalribosomes.BindinganddamagingonthemotifleadstoJNKactivationandsubsequentlybiologicalresponsetothesignalinitiator,whichisnamedribotoxicstressresponse.

简介：InordertodevelopclinicaldiagnostictoolsforrapiddetectionofSARS-CoV(severeacuterespiratorysyndrome-associatedcoronavirus)andtoidentifycandidateproteinsforvaccinedevelopment,theC-terminalportionofthenucleocapsid(NC)genewasamplifiedusingRT-PCRfromtheSARS-CoVgenome,clonedintoayeastexpressionvector(pEGH),andexpressedasaglutathioneS-transferase(GST)andHisx6double-taggedfusionproteinunderthecontrolofaninduciblepromoter.WesternanalysisonthepurifiedproteinconfirmedtheexpressionandpurificationoftheNCfusionproteinsfromyeast.Todetermineitsantigenicity,thefusionproteinwaschallengedwithserumsamplesfromSARSpatientsandnormalcontrols.TheNCfusionproteindemonstratedhighantigenicitywithhighspecificity,andtherefore,itshouldhavegreatpotentialindesigningclinicaldiagnostictoolsandprovideusefulinformationforvaccinedevelopment.

简介：P28，a28kDproteinfromtoad(Bufobufogargarizans)oocytes,wasidentifiedbyusingP13^suc1-agaroseaffinitychromatography.Sequencehomologyanalysisofthefull-lengthcDNAofP28(GeneBankaccessionnumber:AF314091)indicatedthatitencodesaproteincontaining224amino-acidswithabout55%iden-titiesandmorethan70%positivestoencodesaproteincontaining224amino-acidswithabout55%iden-titiesandmorethan70%positivestohuman,ratormouseUCH-L1,andcontainshomologicalfunctionaldomainsofUCHfamily.Anti-p28monoclonalantibody,oninjectingintotheoocytes,couldinhibittheprogesterone-inducedresumptionofmeioticdivisioninadose-dependentmanner.TherecombinantproteinP28showedsimilarSDS/PAGEbehaviorstothenativeone,andpromotedubiquitinethylesterhydrolysis,aclassicalcatalyticreactionforubiquitincarboxylterminalhydrolases(UCHs).Theresultsinthispaperrevealthatanovelprotein,p28,existsinthetoadoocytes,isaUCHLlhomolog,wasengagedintheprocessofprogesterone-inducedoocytematurationpossiblythroughaninvolvementinproteinturnoveranddegradation.

简介：滑动模式控制(FTSMC)计划的一个新奇模糊终端为秒顺序的一个类追踪非线性的不明确的系统的位置被建议。在建议计划，我们集成输入产量linearization技术取消非线性。由使用扩充afunction的滑动亢奋的飞机，追踪错误的产量在能任意地被设置的有限时间收敛到零，这被保证。建议计划消除到达阶段问题，以便靠近环的系统总是显示出不变性性质到参数不确定性。模糊逻辑系统被用来接近未知系统功能和开关条款。Robustadaptive法律被建议减少在真非线性的函数和模糊系统之间的近似错误，因此啁啾的现象能被消除。建议控制计划的稳定性被证明，计划被用于一个转换摆钟系统。模拟研究被提供证实建议控制途径的性能和有效性。

简介：Mobileplatformisnowwidelyseenasapromisingmultimediaservicewithafavorableusergroupandmarketprospect.Tostudytheinfluenceofmobileterminalmodelsonthequalityofsceneroaming,aparametersettingplatformofmobileterminalmodelsisestablishedtoselecttheparameterselectionandperformanceindexondifferentmobileplatformsinthispaper.Thistestplatformisestablishedbasedonmodeloptimalityprinciple,analyzingtheperformancecurveofmobileterminalsindifferentscenemodelsandthendeducingtheexternalparameterofmodelestablishment.Simulationresultsprovethattheestablishedtestplatformisabletoanalyzetheparameterandperformancematchinglistofamobileterminalmodel.

简介：预言潜水艇的能力从它的顺序的蛋白质的细胞的本地化是很重要的，它关于蛋白质的功能提供信息。我们在场一个计算工具，PredSL，它利用神经网络，Markov链，隐藏的Markov建模的侧面，和得分为潜水艇的预言的矩阵在从N终端氨基酸顺序的真核细胞的房间的蛋白质的细胞的本地化。它试图分类蛋白质进五个组：叶绿体，thylakoid，线粒体，能分泌的小径，和“其它”。当在一个五倍的交叉验证过程测试了时，PredSL分别地为植物和非植物数据集表明86.7%和87.1%全面精确性。与TargetP，迄今为止是最广泛地使用的方法，和LumenP相比，PredSL的结果在大多数情况中是可比较的。当在Saccharomycescerevisiae染色体的试验性地验证的蛋白质上测试了时，PredSL可比较地表现如果比为一样的任务的任何可得到的算法不好。而且，PredSL是为这些的预言有能力的唯一的方法代替作为通过URL:http://bioinformatics.biol.uoa.gr/PredSL/的独立应用可得到的细胞的本地化。

简介：ReactionofperfluoroalkyliodideswithaseriesofalkynesundersulfinatodehalogenationconditiongaveamixtureofE/Zadductsveryreadilyinhighyield,thusconstitutedamild,convenientandeffectivenewmethodfortheadditionofperfluoroalkyliodidestoalkynes.Underthesamecon-dition,inthepresenceof1-hexyneperfluoroalkylbromideand1,1,1-trichlorotrifluoroethanereactedonlytogivesulfinatesasthemajorproducts.Aradicalmechanismwasproposedfortheadditionreaction.