简介：SincePresidentObamaannouncedthePrecisionMedicineInitiativeintheUnitedStates,moreandmoreattentionhasbeenpaidtoprecisionmedicine.However,clinicianshavealreadyusedittotreatconditionssuchascancer.Manycardiovasculardiseaseshaveafamilialpresentation,andgeneticvariantsareassociatedwiththeprevention,diagnosis,andtreatmentofcardiovasculardiseases,whicharethebasisforprovidingprecisecaretopatientswithcardiovasculardiseases.Large-scalecohortsandmultiomicsarecriticalcomponentsofprecisionmedicine.Herewesummarizetheapplicationofprecisionmedicinetocardiovasculardiseasesbasedoncohortandomicstudies,andhopetoelicitdiscussionaboutfuturehealthcare.

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简介：LocatedonthecoastoftheYellowSea,theQingdaoQianshaoPresisionMachineryCorporationisakeyenterpriseinChinaAeronauticIndustrialGeneralCorporationandisanationalexporterofmachineryandelectricalproducts.Thecorporationhasabout10subsidiariesandresearchinstitutes.Overthepastdecade,ithassetuptheKelinTechnologicalDevelopmentCorporation,theQingdaoYongqianElectronicsMeasuringEquipmentCo.Ltd,aSino-

简介：Somehavesuggestedtheterm“Precision”medicinereplace“Personalized”medicine.Idon’tlikeeithertermandI’lltellyouwhy.WhatisPrecision?ThewordPrecisioncanbedefinedsimplyasreproducibilityanddoesnotnecessarilymeanthatthediagnosisisaccurate.Thus,ifthemedicaldecisionisprecisebutnotnecessarilyaccurateitisnotveryuseful.Accuracyisdefinedasbeingneartothetrueordesiredvalue.e.g.consideratargetonariflerange;iftheshotshaveatightgroupinganywhereonthetarget,theyareprecisebuttheyareonlypreciseandaccurateifthattightgroupingisintheBull’seye.

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简介：AbstractOver the last 20 years, it has become possible to use a precision medicine approach to the management of chronic obstructive pulmonary disease (COPD). Clinical and physiological features as well as a blood biomarker can be used to target treatments to patients most likely to benefit and avoid treatment in patients less likely to benefit. Future advances in a precision medicine approach to COPD will depend on more precise characterization of individual patients, possibly using quantitative imaging, new physiological techniques, novel biomarkers and genetic profiling. Precision medicine has led to significant improvements in the management of COPD and clinicians should use all available information to optimize the treatment of individual patients.

简介：Accordingtothecharacteristicofthesensorinertia,thedynamicpredictiontoimprovethesystemdynamicprecisionispresentedinthispaper.Withtherecurrencecalculationoftimeconstantofthesensor,thesystemdynamicprecisionisgreatlyimproved.Theexampleusingthismethodisgiven.

简介：挑战性的微型卫星收费载重的精确轨道决心(捣烂)卫星基于位置和在武汉大学里被开发的航行数据分析家(熊猫)软件被做，用从白天126～131的年2002的机载的GPS数据。Theorbit精确性被从GFZprocessed以后科学轨道(PSO)分析差别估计，GPS搬运人和伪范围数据剩余和变化的卫星激光(SLR)剩余。

简介：WiththehelpofCCDimages,therealizationofhighprecisionpo-sitioningandmeasurementhasbecomethebasicstandardformachinevisionandrealtimephotogrammetrysystems.However,deformationandothersortsofdegradationoccurringduringtransmissionaremajorlimitingfactorsofthepreci-sionattainablewithmostcurrentCCDcamerasandframegrabbers.SoapreciseradiometricandgeometrictransmissionofimagesfromCCDsensortomemoryisafundamentalaspectofCCDcameracalibration.Thegeometriccalibrationsystem,whichusessomeimageprocessingalgorithmsoftheCCDcamerabasedonthere-searchedanddevelopedsystemisdiscussed.Thereliabilityandvalidityarealsodiscussed.TheexperimentalresultsforthecalibrationoftheCCDarraywillbetakenasanimportantqualityindexforCCDevaluation.

简介：AbstractImmunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools based on high-throughput sequencing data, mass spectrometry data, and biological databases. Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines, neoantigen-specific CD8+ and CD4+ T cells, and neoantigen-pulsed dendritic cells. In addition, neoantigens can be used as biomarkers to assess immunotherapy response, resistance, and prognosis. Therapies based on neoantigens are an important and promising branch of cancer immunotherapy. Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application. This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy.

简介：Inthispaper,theX-raynondestructivetestmethodofsmalldefectsinprecisionweldmentswithcomplexstructurewaspresented.Toresolvethedifficultyofdefectsegmentationinvariablegreyimage,theimageprocessingbasedonVisualBasicprogrammingmethodwasadopted.ThemethodsofautomaticcontrastandpartialgreystretchwereusedtoenhancetheX-raydetectionimagewhichhasrelativelylowcontrast,thenautomaticthresholdmethodwascarriedouttosegmentthetwohighintensityzones,andweldzoneswhichcontainthesmalldefectswasextracted.Smoothingandsharpenprocessingwereproceededontheextractedweldzones,andsmalldefectsinX-raydetectionimageofweldmentswithcomplexstructureweresegmentedbyusingthemethodofbackgroundsubtractionintheend.Theeffectsofrasterwereeliminated,andbecauseofthattheimageprocessingwasonlyproceededontheextractedweldzones,thecalculatedspeedusingtheaboveprovidedalgorithmwasimproved.

简介：ＯＮＴＨＥＨＩＧＨＰＲＥＣＩＳＩＯＮＡＤＡＰＴＩＶＥＯＰＥＮＢＯＵＮＤＡＲＹＣＯＮＤＩＴＩＯＮＳＦＯＲＴＲＡＮＳＩＥＮＴＷＡＶＥＳ￥ＺｏｕＧｕａｎｇ－ｙｕａｎ（Ｄｅｐｔ．ｏｆＭｅｃｈａｎｉｃｓａｎｄＥｎｇｉｎｅｅｒｉｎｇＳｃｉｅｎｃｅｓ，Ｐｅｋｉｎｇ...

简介：Currentlytheclinicalmanagementofbreastcancerreliesonrelativelyfewprognostic/predictiveclinicalmarkers(estrogenreceptor,progesteronereceptor,HER2),basedonprimarytumorbiology.Circulatingbiomarkers,suchascirculatingtumorDNA(ctDNA)orcirculatingtumorcells(CTCs)mayenhanceourtreatmentoptionsbyfocusingontheverycellsthatarethedirectprecursorsofdistantmetastaticdisease,andprobablyinherentlydifferentthantheprimarytumor'sbiology.Toshiftthecurrentclinicalparadigm,assessingtumorbiologyinrealtimebymolecularlyprofilingCTCsorctDNAmayservetodiscovertherapeutictargets,detectminimalresidualdiseaseandpredictresponsetotreatment.Thisreviewservestoelucidatethedetection,characterization,andclinicalapplicationofCTCsandctDNAwiththegoalofprecisiontreatmentofbreastcancer.

简介：马达的配置被设计，动态分析方程基于它的简化模型被推出。利用栅栏的一个严峻的系统被设置测试这台新马达，和理论运动原则因为马达被实验证明。脉搏波形被使用驱使马达搬到步。马达有10nm和0.6mm/s的最大的速度的一个排水量决定。它能驾驶其范围是20公里的200g滑块。放站台的一个维的精确被使用新混合压电的马达制作。原型由二台伺服马达和二台压电的马达组成，它被一台计算机自动地控制。站台的放的范围是10厘米。

简介：ThispaperpresentsanewPulseWidthModulation(PWM)controllerforUnmannedAerialVehicle(UAV)precisionsprayerforagricultureusingaTL494fixed-frequencypulsewidthmodulatortogetherwithadataacquisitionboardanddevelopedsoftware.AnUAVcanberemotelycontrolledorflownautonomouslybypre-programmedflightplans.ThePWMcontrollerwasimplementedthroughtheguidancesystemontheUAVwithcontrolcommandssentbetweentheUAVhelicopterandthegroundcontrolstationviaawirelesstelemetrysystem.ThePWMcontrollerwastestedandvalidatedusingLabVIEW8.2.Severalanalyseswereperformedinalaboratorytotestdifferentcontrolsignals.TheresultsshowthatthePWMcontrollerhaspromiseasahigherprecisiontechniqueforsprayapplications,whichwillimproveefficiencyofpesticideapplication,especiallyincropproductionareas.

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简介：Inthispaper,theoperationprincipleoflaserrotaryencodersisexpoundedandtheopticalquadruplefrequencytechnologyusedinlaserrotaryencodersinex-plained,andthedesignideaofopticalsysteminΦ66mmlaserrotaryencoderismainlyintroduced,aswellasthechoiceofprincipaldevices.

简介：Accordingtothepreciseephemerishasonlyprovidedsatellitepositionthatisdiscretenotanytime,soproposethatmakeuseofinterpolationmethodtocalculatesatellitepositionatanytime.TheessaytakeadvantageofIGSpreciseephemerisdatatocalculatesatellitepositionatsometimebyusingLagrangeinterpolation,Newtoninterpolation,Hermiteinterpolation,Cubicsplineinterpolationmethod,Chebyshevfittingmethodrespectively,whichhasadeeplyanalysisintheprecisionoffiveinterpolations.TheresultsshowthattheprecisionofCubicsplineinterpolationmethodistheworst,theprecisionofChebyshevfittingisbetterthanHermiteinterpolationmethod.LagrangeinterpolationandNewtoninterpolationarebetterthanothermethodsinprecision.Newtoninterpolationmethodhastheadvantagesofhighspeedandhighprecision.Therefore,Newtoninterpolationmethodhasacertainscientificsignificanceandpracticalvaluetogetthepositionofthesatellitequicklyandaccurately.

简介：Thispaperfocusesonhowtobuildthemodelofprecisionfirehazarddivisionsinthelevelofforestresourcessub-compartment.Basedon3DGIStechnologyandcharacteristicsofforestfiresincollectiveforestofsouthernChina,thisstudyutilizedLin’anCity,ZhejiangProvinceastheexperimentalarea.Forestfirefactorsweredividedinto11indexesfromthethreecategories(socialandeconomicfactors,forestrycharacteristics,andmeteorologicalcharacteristics)andweightedforanalysis.Next,threeeigenvectors(oneforeachcategory)werecreatedtobuildanonlinearmathematicalmodelcalledprecisionfirehazarddivisionsforforests.Then,themodelwasusedtooptimizeandtestforestfirehazarddivisionswiththeleastsquares.Resultsshowedthatexperimentalandtheoreticalvaluesoferrorwerelessthan0.1.Thus,intheexperimentalareathismodelandthefireoccurrencehistorymatched.

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