摘要
AbstractImmunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools based on high-throughput sequencing data, mass spectrometry data, and biological databases. Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines, neoantigen-specific CD8+ and CD4+ T cells, and neoantigen-pulsed dendritic cells. In addition, neoantigens can be used as biomarkers to assess immunotherapy response, resistance, and prognosis. Therapies based on neoantigens are an important and promising branch of cancer immunotherapy. Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application. This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy.
机构地区
Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing 400037, China Department of Hematology and Oncology, The 988th Hospital of Joint Logistic Support Force of PLA, Kaifeng, Henan 475003, China,Institute of Cancer, Xinqiao Hospital, Army Medical Universit
出版日期
2022年12月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
