简介：Objective:ThisstudyaimstoexploretheassociationbetweenthedensityofHimalayanmarmot(Marmotahimalayana)andclimaticfactorssuchastemperature,precipitation,humidity,vapourpressure,sunshinepercentage,windvelocity,whicharecloselyassociatedwithglobalclimatechange,andtoprovideareferenceforplaguepreventionandcontrol.Methods:WeconductedaregressionanalysistofindthepossibleclimatefactorsassociatedwiththedensityofHimalayamarmot,andanalyzedtheresponsecharactersofHimalayanmarmottoclimatechange.Results:Dailyprecipitationdays(>=0.1mm)andsunshinepercentageweresignificantlyassociatedwiththedensityofHimalayanmarmot(p<0.01).Conclusion:Climatechangewasassociatedwiththeriskofplague.ThisphenomenonisvaluableforHimalayanmarmotandplagueprevention.MorestudiesareneededtounderstandtheimpactofclimatechangeonHimalayanmarmotandplague.

简介：最当前的地震设计通过反应减小因素(R)包括结构的非线性的反应。这允许设计者当为非线性的行为和变丑的财务限制时，使用一条线性有弹性的基于力量的途径。事实上，反应减小因素在现代地震代码被使用按比例缩小结构的有弹性的反应。这研究集中于为增强的水泥(RC)的设计设计/构造估计实际R价值在Kathmandu的大楼山谷。韧性并且在Kathmandu的代表性的RC大楼编制被调查。非线性的闲差事分析在结构的模型上被执行以便评估大楼的地震表演。有位于Kathmandu山谷的许多特征的12座代表性的设计不规则的大楼被选择并且学习。而且，效果在韧性因素，造的韧性上的横梁列能力比率，和反应减小因素上的负担路径上编制，被检验。最后，结果进一步被分析并且与大楼的不同结构的参数相比。

简介：让G是2是的一张图，和k一个积极整数。图G是部分independentset-deletablek-factor-critical(简言之，部分ID-k-factor-critical)，如果官方补给为每个独立人士的部分k因素设定我G。有约束力的数字绑图G的(G)被定义为$$bind(G)=min\left\{{\frac{{\left|{N_G(X)}\right|}}{{\left|X\right|}}:\not0\neX\subseteqV(G)，N_G(X)\neV(G)}\right\}在这份报纸的.$$，如果，图G是部分ID-k-factor-critical，这被证明如果n6k9并且绑(G)$>\frac{{(3k-1)(n-1)}}{{kn-2k+2}}$。

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简介：Resultsofanexperimentalstudyontheeffectsofdifferentconcentrationsofwashloadonthesizeofbedfeaturesandresistancetoflowinalaboratoryflumearepresented.Theexperimentswerecarriedoutunderdifferenthydraulicconditionsina30mlong,0.204mwideand0.5mdeeptiltingflumeunderclearwaterconditionandinthepresenceofdifferentconcentrationofwashloadintheflow.Thebedmaterialusedconsistedofuniformsedimentofsize0.96mm.Analysisofthedataindicatesthatthecharacteristicsofthebedfeatureschangeandfrictionfactorincreasesinthepresenceofdifferentconcentrationofwashloadintheflow.Thereasonsforchangesinthecharacteristicsofthebedfeaturesandincreaseinfrictionfactorinthepresenceofwashloadareidentifiedandarelationshipforpredictingfrictionfactorinthepresenceofwashloadhasbeenestablished.

简介：巨噬细胞在免疫和动态平衡起一个重要作用。在经由特定的受体的病原体识别之上，他们很快导致煽动性的回答。这个过程紧在transcriptional水平被控制。DNA有约束力的锌手指蛋白质CCCTC有约束力的因素(Ctcf)是远程的染色质相互作用的一个关键管理者并且协调在抄写因素和基因表达式进程之间的特定的通讯。在这研究，Ctcf基因被使用转基因的Cre-LoxP系统明确地在myeloid房间删除。在myeloid房间的Ctcf基因的有条件的删除在vivo导致了温和显型。显著地展出的Ctcf缺乏的老鼠减少了主要histocompatibility的表示在肝的建筑群(MHC)班II。Ctcf缺乏的巨噬细胞表明了正常表面显型和吞噬作用能力。在像使用费的受体(TLR)之上刺激，他们生产了支持inflammatorycytokinesIL-12和IL-6的正常层次，但是表明了一个强烈损害的能力生产肿瘤坏死因素(TNF)和IL-10，以及表示IL-10家庭成员IL-19，IL-20和IL-24。一起拿，我们的数据表明涉及巨噬细胞功能调整的Ctcf的一个角色。

简介：TheSCIimpactfactorofJournalofNaturalGasChemistry(JNGC)is1.788,accordingtothe'2013JournalCitationReports(JCR)ScienceEdition'.ThisisthehighestSCIimpactfactorforJournalofNaturalGasChemistrysincethejournalwasincludedintheScienceCitationIndexExpanded(SCIE)in2007,anditranksfirstamongchemistryjournalsinChina.Overthepastdecade,theJournalofNaturalGasChemistryhasbecomemoreandmoreinternationalandhasreceivedlargenumbersofmanuscriptsconcerningenergychemistry.Indeed,nowadaysenergychemistryisbecomingoneofthehottopics.

简介：Carbonnanotubescancarryproteinintocellstoinducebiologicaleffects.Amino-functionalizedcarbonnanotubesaresolubleandbiocompatible,havehighreactivityandlowtoxicity,andcanhelppromotenervecellgrowth.Inthisstudy,amino-functionalizedethylenediamine-treatedmulti-walledcarbonnanotubeswereusedtopreparecarbonnanotubes-nervegrowthfactorcomplexesbynon-covalentgrafting.Thephysicochemicalproperties,cytotoxicitytoPC12andchickembryodorsalrootganglion,andbiologicalactivityofthecarbonnanotubes-nervegrowthfactorcomplexeswereinvestigated.Theresultsshowedthataminofunctionalizationimprovedcarbonnanotubes-nervegrowthfactorcomplexdispersibility,reducedtheirtoxicitytoPC12cells,andpromotedPC12celldifferentiationandchickembryodorsalrootganglion.

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简介：Hypoxia-induciblefactor1(HIF-1)attenuatesamyloid-betaproteinneurotoxicityanddecreasesapoptosisinducedbyoxidativestressorhypoxiaincorticalneurons.Inthisstudy,weconstructedarecombinantadeno-associatedvirus(rAAV)vectorexpressingthehumanHIF-1αgene(rAAV-HIF-1α),andtestedtheassumptionthatrAAV-HIF-1αrepresseshippocampalneuronalapoptosisinducedbyamyloid-betaprotein.OurresultsconfirmedthatrAAV-HIF-1αsignificantlyreducesapoptosisinducedbyamyloid-betaproteininprimaryculturedhippocampalneurons.DirectintracerebralrAAV-HIF-1αadministrationalsoinducedrobustandprolongedHIF-1αproductioninrathippocampus.SinglerAAV-HIF-1αadministrationresultedindecreasedapoptosisofhippocampalneuronsinanAlzheimer’sdiseaseratmodelestablishedbyintracerebroventricularinjectionofaggregatedamyloid-betaprotein(25–35).OurinvitroandinvivofindingsdemonstratethatHIF-1haspotentialforattenuatinghippocampalneuronalapoptosisinducedbyamyloid-betaprotein,andprovidesexperimentalsupportfortreatmentofneurodegenerativediseasesusinggenetherapy.

简介：Homeoboxtranscriptionfactorsparticipateinthegrowthanddevelopmentofplantsbyregulatingcelldifferentiation,morphogenesisandenvironmentalsignalresponse.Torevealthefunctionsofthesetranscriptionfactorsinrice,weconstructedtheRNAivectorsofOsHox9,amemberofhomeoboxfamily,andanalyzedthefunctionofOsHox9usingreversegenetics.TheplantheightandtilleringnumberofRNAitransgenicplantsdecreasedcomparedwiththoseofwild-typeplants.Reversetranscription-polymerasechainreactionanalysisshowedthatOsHox9expressionreducedinthetransgenicplantswithphenotypicvariance,whereasthatinthetransgenicplantswithoutphenotypicvariancewassimilartothatinthewild-typeplants.ThisresultsuggeststhatthephenotypesofthetransgenicplantswerecausedbyRNAieffects.Thetissue-specificityofOsHox9expressionindicatedthatitwasexpressedindifferentorgans,withhighexpressioninstemapicalmeristemandyoungpanicles.SubcellularlocationofOsHox9demonstratedthatitwaslocalizedonthecellmembrane.

简介：AIM:Toinvestigatethemorphologicalalteringeffectoftransforminggrowthfactor-β2(TGF-β2)onuntransfectedhumancornealendothelialcells(HCECs)invitro.METHODS:AfteruntransfectedHCECsweretreatedwithTGF-β2atdifferentconcentrations,themorphology,cytoskeletondistribution,andtypeIVcollagenexpressionofthecellswereexaminedwithinvertedcontrastlightmicroscopy,fluorescencemicroscopy,immunofluorescenceorWesternBlot.RESULTS:TGF-β2attheconcentrationof3-15μg/LhadobviouslyalterativeeffectsonHCECsmorphologyindoseandtime-dependentmanner,and9μg/Lwasthepeakconcentration.TGF-β2(9μg/L)alteredHCEcellmorphologyaftertreatmentfor36h,increasedthemeanopticaldensity(P<0.01)andthelengthofF-actin,reducedthemeanopticaldensity(P<0.01)ofthecollagentypeIVinextracellularmatrix(ECM)andinducedtherearrangementofF-actin,microtubuleincytoplasmandcollagentypeIVinECMaftertreatmentfor72h.·CONCLUTION:TGF-β2hasobviouslyalterativeeffectonthemorphologyofHCECsfrompolygonalphenotypetoenlargedspindle-shapedphenotype,indoseandtime-dependencemannerbyinducingmore,elongationandalignmentofF-actin,rearrangementofmicrotubuleandlargerspreadareaofcollagentypeIV.

简介：Neuroprotectionbyischemicpreconditioninghasbeenconfirmedbymanystudies,buttheprecisemechanismremainsunclear.Inthepresentstudy,weperformedcerebralischemicpreconditioninginratsbysimulatingatransientischemicattacktwice(eacha20-minuteocclusionofthemiddlecerebralartery)beforeinducingfocalcerebralinfarction(2hourocclusion-reperfusioninthesameartery).Wealsoexploredthemechanismunderlyingtheneuroprotectiveeffectofischemicpreconditioning.Sevendaysafterocclusion-reperfusion,tetrazoliumchloridestainingandimmunohistochemistryrevealedthattheinfarctvolumewassignificantlysmallerinthegroupthatunderwentpreconditioningthaninthemodelgroup.Furthermore,vascularendothelialgrowthfactorimmunoreactivitywasconsiderablygreaterinthehippocampalCA3regionofpreconditionedratsthanmodelrats.Ourresultssuggestthattheprotectiveeffectsofischemicpreconditioningonfocalcerebralinfarctionareassociatedwithupregulationofvascularendothelialgrowthfactor.

简介：Endothelialprogenitorcellsareresidentinthebonemarrowbloodsinusoidsandcirculateintheperipheralcirculation.Theymobilizefromthebonemarrowaftervascularinjuryandhometothesiteofinjurywheretheydifferentiateintoendothelialcells.Activationandmobilizationofendothelialprogenitorcellsfromthebonemarrowisinducedviatheproductionandreleaseofendothelialprogenitorcell-activatingfactorsandincludesspecificgrowthfactorsandcytokinesinresponsetoperipheraltissuehypoxiasuchasafteracuteischemicstrokeortrauma.Endothelialprogenitorcellsmigrateandhometospecificsitesfollowingischemicstrokeviagrowthfactor/cytokinegradients.Somegrowthfactorsarelessstableunderacidicconditionsoftissueischemia,andsyntheticanaloguesthatarestableatlowpHmayprovideamoreeffectivetherapeuticapproachforinducingendothelialprogenitorcellmobilizationandpromotingcerebralneovascularizationfollowingischemicstroke.

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简介：TheresistivityexperimentalmeasurementsofcoresamplesdrilledfromlowpermeabilityreservoirsofOrdosBasin,NorthwestChina,illustratethatthecementationfactorsarenotagminate,butvaryfrom1.335to1.749.Thisleadstoachallengefortheestimationofwaterandhydrocarbonsaturation.BasedontheanalysisofPurcellequationandassumptionthatrockresistivityisdeterminedbytheparallelconnectionofnumerouscapillaryresistances,atheoreticalexpressionofcementationfactorintermsofporosityandpermeabilityisestablished.Then,cementationfactorcanbecalculatediftheparametersofporosityandpermeabilityaredetermined.Inthefieldapplication,porositycanbeeasilyobtainedbyconventionallogs.However,itisatoughchallengetoestimatepermeabilityduetothestrongheterogeneityoflowpermeabilityreservoirs.Thus,theSchlumbergerDollResearch(SDR)modelderivedfromNMRlogshasbeenproposedtoestimatepermeability.BasedontheanalysisofthetheoreticalexpressionsofcementationfactorandSDRmodel,anovelcementationfactorpredictionmodel,whichisrelevanttoporosityandlogarithmicmeanofNMRT2spectrum(T2lm),isderived.TheadvantageofthismodelisthatalltheinputinformationcanbeacquiredfromNMRlogsaccurately.Inordertoconfirmthecredibilityofthenovelmodel,theresistivityandcorrespondinglaboratoryNMRmeasurementsof27coresamplesareconducted.Thecredibilityofthemodelisconfirmedbycomparingthepredictedcementationfactorswiththecoreanalyzedresults.Theabsoluteerrorsforallcoresamplesarelowerthan0.071.Oncethismodelisextendedtofieldapplication,theaccuracyofwaterandhydrocarbonsaturationestimationwillbesignificantlyimproved.

简介：在CD4系抄写因素ThPok和CD8系抄写因素之间的相互影响，老牛相关的抄写因素3(Runx3)，在T房间，开发广泛地被记录了。然而，很少在不变的自然漂亮T(iNKT)房间开发对这些抄写因素的角色被知道。限制CD1d的iNKT房间承诺CD4+CD8−和CD4−CD8−sublineages，它对抗原刺激作出回应与快速并且T助手(Th)的有势力版本1并且Th2cytokines。然而，以前的报告在ThPok缺乏的老鼠表明了CD8+NKT房间的一张新人口。在当前的学习，我们寻求了决定Runx3是否当ThPok不在时涉及CD8的重新表示和iNKT房间的功能。我们使用了缺乏Runx3，ThPok或两个的老鼠并且证实Runx3为在ThPok猛烈老鼠的CD8+iNKT房间的外观部分负责。另外，Runx3参予了有免疫力的反应在α的一个模型由iNKT房间调停了；-galactosylceramide-induced尖锐肝炎。这些结果显示Runx3为在ThPok缺乏的iNKT房间观察的phenotypic和功能的变化是关键的。

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