简介：[题目]原位组装纳米银粒子（AgNPs）至多孔蚕茧基膜：具有增强抗菌和促进伤口愈合活性[]防止伤口感染并保持伤口刷围适当的水分是伤口处理中最关键的问题。YuK等人为了研究这个问题，选用保护作用类似于人体皮肤功能的桑蚕茧为研究材料。

简介：1.SongzhenHe,XiaolingTong,KunpengLu,YaruLu,JiangwenLuo,WenhaoYang,MinChen,Min-jinHan,HaiHu,ChengLu,FangyinDai.ComparativeAnalysisofTranscriptomesamongBombyxmoriStrainsandSexesRevealstheGenesRegulatingMelanicMorphandtheRelatedPhenotypes.PloSONE.2016,11（5）：e0155061.doi：10.1371/journal.pone.0155061[题目][题目]不同品种及性别家蚕的转录组比较分析揭示黑化调节基因和相关的表型，

简介：1.WANGP,BIS,WEIW,QIUZ,XIAD,SHENX,ZHAOQ.Downregulationofaldosereductaseisresponsiblefordevelopmentalabnormalitiesofthesilkwormpurplequail-likemutant（q-l-p）.Gene.DOI：10.1016/j.gene.2018.05.010（2018）.

简介：Changesinneurocognitivefunctioningandqualityoflifeinadultpatientswithbraintumorstreatedwithradiotherapy.

简介：PURPOSE：Vorinostat,ahistonedeacetylaseinhibitor,representsarationaltherapeutictargetinglioblastomamultiforme（GBM）.PATIENTSANDMETHODS：PatientswithrecurrentGBMwhohadreceivedoneorfewerchemotherapyregimensforprogressivediseasewereeligible.

简介：Markedresponseofgliomatosiscerebritotemozolomideandwholebrainradiotherapy.

简介：PURPOSE：ResistancetotemozolomidechemotherapyispartlymediatedbyO^6-methylguanine-DNAmethlytransferase（MGMT）.ProtractedtreatmentwithtemozolomidepotentiallyovercomesMGMTresistanceandimprovesoutcome.WeconductedaphaseIIstudyofprotracteddailytemozolomideinadultswithlow-gradegliomas.EXPERIMENTALDESIGN：PatientswithnewlydiagnosedoligodendrogliomaoroligoastrocytomawithaMIB-1indexof〉5%orrecurrentlow-gradegliomasreceivedtemozolomide（75mg/m^2/dayin11-weekcyclesof7weekson/4weeksoff）.Treatmentcontinuedforatotalofsixcyclesoruntiltumorprogressionorunacceptabletoxicity.Primaryendpointwasbestoverallresponserate;secondaryendpointswereprogression-freesurvival,overallsurvival,andtoxicity.

简介：BACKGROUND：In2004,arandomisedphaseⅢtrialbytheEuropeanOrganisationforResearchandTreatmentofCancer（EORTC）andNationalCancerInstituteofCanadaClinicalTrialsGroup（NCIC）reportedimprovedmedianand2-yearsurvivalforpatientswithglioblastomatreatedwithconcomitantandadjuvanttemozolomideandradiotherapy.We＇reportthefinalresultswithamedianfollow-upofmorethan5years.METHODS：Adultpatientswithnewlydiagnosedglioblastomawererandomlyassignedtoreceiveeitherstandardradiotherapyoridenticalradiotherapywithconcomitanttemozolomidefollowedbyuptosixcyclesofadjuvanttemozolomide.

简介：Monochromaticminibeamsradiotherapy：fromhealthytissue-sparingeffectstudiestowardfirstexperimentalgliomabearingratstherapy.

简介：PURPOSE：Toevaluatethetoxicityandresponserateofbortezomibwithconcurrentradiotherapyandtemozolomideinthetreatmentofpatientswithcentralnervoussystemmalignancies.PATIENTSANDMETHODS：Thisopen-label,dose-escalation,PhaseⅠclinicalstudyevaluatedthesafetyofthreedoselevelsofintravenouslyadministeredbortezomib（0.7,1.0,and1.3mg/m（2）/dose）onDays1,4,8,and11ofa21-daycycle,inadditiontoconcurrentradiotherapyandtemozolomideatadailydoseof75mg/m（2）startingonDay1.Theprimaryendpointwasdose-limitingtoxicity,definedasanyGrade4-5toxicityorGrade3toxicitydirectlyat-tr/butabletoprotocoltreatment,requiringhospitalizationand/orradiotherapyinterruption.

简介：研发前言Rockwell科学公司开发高温SiC电机传动系统Rockwell科学公司与美国空军研究实验室将共同开发高效、高温和小型的电机传动系统,应用于飞机和太空船。该项目主要开发基于SiC(碳化硅半导体)开关的磁阻电机传动,检验在200℃工作的容错电气传动装置。开发这种能在几乎无冷却的恶劣环境下工作的电机传动系统,关键是研发高温SiC开关,封装,控制电子学和电机。这些装置将显著降低电力电子的尺寸和重量。

简介：PURPOSE：ThisphaseⅡtrialwasdesignedtodefinetheroleofO^6-benzylguanine（O^6-BG）inrestoringtemozolomidesensitivityinpatientswithrecurrentorprogressive,temozolomidc-resistantmalignantgliomaandtoevaluatethesafetyofadministeringO^6-BGincombinationwithtemozolomide.PATIENTSANDMETHODS：Patientswereaccruedintotwoindependentstrataonthebasisofhistology：glioblastomamultifonne（GBM）andaanaplasticglioma.BothtemozolomideandO6-BGwereadministeredonday1ofa28-daytreatmentcycle.Patientswereadministereda1-hourO^6-BGinfusionatadoseof120mg/m^2followedimmediatelybya48-hourinfusionatadoseof30mg/m^2/d.

简介：PURPOSE：Toevaluatesingle-agentactivityofbevacizumabinpatientswithrecurrentglioblastoma.PATIENTSANDMETH-ODS：Patientswithrecurrentglioblastomaweretreatedwithbevacizumab10mg/kgevery2weeks.Aftertumorprogression,patientswereimmediatelytreatedwithbevacizumabincombinationwithirinotecan340mg/m^2or125mg/m^2every2weeks,dependingonuseofenzyme-inducingantiepilepticdrugs.Completepatientevaluationswererepeatedevery4weeks.RESULTS：Forty-eightheavilypretreatedpatientswereaccruedtothisstudy.Thromboembolicevents（12.5%）,hypertension（12.5%）,hypophosphatemia（6%）,andthrombocytopenia（6%）werethemostcommondrug-associatedadverseevents.Sixpatients（12.5%）wereremovedfromstudyfordrug-associatedtoxicity（fivethromboembolicevents,onebowelperforation）.

简介：

简介：PURPOSE：Fotemustineisanitrosoureacompoundusedforthetreatmentofmalignantgliomas,especiallyinFrance.Recently,anEORTC-NCICstudyhasshownthataconcomitantcombinationofradiotherapyplustemozolomide（anoralcytotoxicdrug）improvedsurvivalinglioblastomapatients.Wesetouttotestaconcurrentcombinationofradiotherapyandfotemustinefornewlymalignantgliomas.

简介：BACKGROUND：SupratentorialPNET（sPNET）arerareCNStumorsofembryonaloriginarisinginchildrenandadults.Thetreat-mentofsPNETforallagegroupsatourcancercenterhasbeenbasedonthemanagementofmedulloblastoma（MB）,involvingneurosurgicaldebulkingfollowedbyeranio-spinalirradiation（CS1）andsystemicchemotherapy.METHODS：MedicalrecordswerereviewedtogatherdemographicandclinicaldataaboutallembryonalCNStumorsinchildrenandadultsfrom2001to2007.Tumorpathology,clinicalmanagementandsurvivaldatawerealsoassessed,particularlyasregardsthosepatientswhoreceivedthePackerchemotherapyregimenforeithersPNETorMB.

简介：Humanglioblastomas(GBM)arethoughttobeinitiatedbygliomastem-likecells(GSLCs).GSLCsalsoparticipateintumorneovascularizationbytransdifferentiatingintovascularendothelialcells.Here,wereportacriticalroleofGSLCsintheformationofvasculogenicmimicry(VM),whichdefineschannelslinedbytumorcellstosupplynutrientstoearlygrowingtumorsandtumor

简介：Glioblastomaisoneofthemostangiogenichumantumorsandcharacterizedbymicrovascularproliferations.Abetterunderstandingofglioblastomavasculatureisneededtooptimizeanti-angiogenictherapythathasshownapromisingbutincompleteefficacy.Thepresentstudyexamined48glioblastomasbyCD34endothelialmarkerperiodicacid-Schiff(PAS)dualstainingandfoundnon-endothelialcell-linedblood

简介：RoleofEarlyPostradiationMagneticResonanceImagingScansinChildrenwithDiffuseIntrinsicPontineGlioma.

简介：Prophylacticantiepilepticdrugtherapyinpatientsundergoingsupratentorialmeningiomaresection：asystematicanalysisofefficacy.JNeurosurg.2011Jun3.[Epubaheadofprint]KomotarRJ,RaperDM,StarkeRM,IorgulescuJB,GutinPH.