简介:摘要:近年来,随着血栓栓塞性疾病的发病率及死亡率的上升,新型口服抗凝药对于预防和治疗血栓栓塞性疾病具有重要的临床意义和应用价值。新型口服抗凝药包括凝血因子Ⅹ a抑制剂和直接凝血酶抑制剂,前者主要为利伐沙班、阿哌沙班、依度沙班和贝曲沙班,后者代表药物为达比加群酯,在治疗血栓栓塞性疾病过程中具有无需频繁调整剂量、无需常规监测凝血功能、出血率低等优点。本文对近年来国内外发表的凝血因子Ⅹ a抑制剂治疗血栓栓塞性疾病研究进展的相关文献进行综述,为临床规范化使用凝血因子Ⅹ a抑制剂提供参考。
简介: 【摘要】目的 研究凝血检验指标在弥漫性血管内凝血诊断中的作用效果。方法 抽取 2017年 12月~ 2018年 12月到我院进行弥漫性血管内凝血诊疗的 90例患者作为本次的研究对象,分为研究组,再选择同期到我院进行常规体检的 90例健康人员作为对照组,在其他条件相同的情况下,分别为两组进行弥漫性血管内凝血诊断人员实施凝血指标检验,比较两组检验人员诊断结果中的各项指标。结果 观察组诊疗患者的 APTT、 PT、 INR以及 TT水平明显比对照组健康人员的水平高,而 FIB水平明显比对照组健康人员的水平低,两组进行凝血指标检验的诊断效果差异具有统计学意义( P<0.05)。结论 对弥漫性血管内凝血患者实施凝血指标检验能够有效地诊断出患者的病情发展情况,为主治医生提供了更加可靠的依据对患者进行针对性的治疗,是一项值得推广的应用。 【关键词】凝血检验指标 ;弥漫性血管内凝血 ;健康人员 [Abstract] Objective To study the effect of coagulation test in the diagnosis of DIC. method From December 2017 to December 2018, 90 patients who came to our hospital for diagnosis and treatment of disseminated intravascular coagulation were divided into study group and 90 healthy persons who came to our hospital for routine physical examination at the same time were selected as the control group. Under the same conditions, the coagulation index test was carried out for the two groups for the diagnosis of disseminated intravascular coagulation, and the two groups were compared Each index in the diagnosis results of group B inspectors. Results the levels of APTT, Pt, INR and TT of the patients in the observation group were significantly higher than those in the control group, while the levels of FIB were significantly lower than those in the control group. There was a significant difference between the two groups in the diagnostic effect of coagulation index test (P < 0.05). Conclusion the test of coagulation index can effectively diagnose the development of patients with DIC, and provide a more reliable basis for the attending doctors to carry out targeted treatment for patients, which is worth popularizing.
简介: 摘要目的:探讨标本放置温度、时间及凝血真空采血管对凝血检验的影响。方法: 2018年 3-8月收治体检健康志愿者 80例,应用 2种不同的凝血真空采血管采集标本进行凝血检验。甲组使用 BD凝血真空采血管,乙组使用国产抗凝管。分析不同时间、不同温度对凝血检验结果的影响。结果:两组凝血酶时间( TT)、纤维蛋白原( FIB)、活化部分凝血活酶时间( APTT)、血浆凝血酶原时间( PT)比较,差异无统计学意义( P>0.05) ;低温保存 8h后, TT、 APTT、 PT高于即时检查,差异有统计学意义( P<0.05) ;室温保存 4h后, TT、 PT、 APTT高于即时检查结果,差异有统计学意义( P<0.05) ;FIB在室温、低温保存以及即时检查中差异均无统计学意义( P>0.05)。结论:不同质量的真空采集血管会对检查结果造成一定影响,而保存时间、放置温度均会影响检查结果,为了确保检验的准确性,应选择合适的凝血真空采集管,并在 2h内完成检查。 关键词 凝血检验 ;真空采集血管 ;放置时间 ;放置温度 Objective: To investigate the effects of temperature, time and blood vessel collection on blood coagulation test. Methods: from March to August 2018, 80 healthy volunteers were admitted for physical examination. Two kinds of blood coagulation vacuum blood collection specimens were used for coagulation test. In group A, blood vessels were collected by BD coagulation vacuum, and in group B, anticoagulation tubes made in China were used. The influence of different time and temperature on coagulation test results was analyzed. Results: there was no significant difference in TT, FIB, APTT and Pt between the two groups (P > 0.05); after 8 hours of cryopreservation, TT, APTT and PT were higher than those of the immediate examination (P < 0.05); after 4 hours of room temperature preservation, TT, Pt and APTT were higher than those of the immediate examination (P < 0.05) There was no significant difference in FIB in room temperature, cryopreservation and instant examination (P > 0.05). Conclusion: different quality of vacuum collection vessels will affect the results of the examination, while the storage time and temperature will affect the results of the examination. In order to ensure the accuracy of the examination, we should select a suitable coagulation vacuum collection tube and complete the examination within 2 hours.
简介: 摘要 目的:探究凝血检验指标在诊断弥漫性血管内凝血中的应用价值。方法: 2018年 1月 -2019年 12月收治弥漫性血管内凝血患者 80例为试验组,另取同期健康受检者 80例为对照组。对比凝血检验结果。结果:试验组 PT、 APTT、 TT、 INR水平均高于对照组, FIB水平低于对照组,差异有统计学意义( P<0.05)。试验组高凝期、低凝期及纤溶期 PT、 APTT、 TT、 INR与 FIB水平对比,差异有统计学意义( P<0.05)。结论:采用凝血检验指标可有效检出弥漫性血管内凝血,有助于确定凝血分期。 关键词 凝血检验指标 ;弥漫性血管内凝血 ;诊断 Objective: To explore the application value of coagulation test indexes in the diagnosis of disseminated intravascular coagulation. Methods: from January 2018 to December 2019, 80 patients with disseminated intravascular coagulation were selected as the experimental group, and 80 healthy subjects were selected as the control group. The blood coagulation test results were compared. Results: the levels of Pt, APTT, TT and INR in the experimental group were higher than those in the control group, and the FIB level was lower than that in the control group (P < 0.05). There were statistically significant differences in Pt, APTT, TT, INR and FIB levels in the experimental group at high coagulation stage, low coagulation stage and fibrinolysis stage (P < 0.05). Conclusion: disseminated intravascular coagulation can be detected effectively by coagulation test indexes, which is helpful to determine the coagulation stage.
简介: 摘要:目的 探讨分析凝血检验指标在诊断弥漫性血管内凝血中的临床价值。方法 将于 2017年 1月 -2018年 12月期间收治的弥漫性血管内凝血患者 100例纳入研究,即研究组,并抽取 100例同时间段来院进行健康健康的人群作为对照组;两组均接受凝血检验,并结合检查结果进行分析对比。结果 研究组的 PT、 APTT、 TT、 INR均高于对照组,而 FIB低于对照组, P<0.05;研究组高凝期的 PT、 APTT、 TT、 FIB均低于低凝期及纤溶期,而 INR则明显高于低凝期及纤溶期, P<0.05。结论 应用凝血检验指标诊断弥漫性血管内凝血的临床价值高,更有效评估弥漫性血管内凝血具体疾病分期,值得推广与应用。 关键词:凝血检验指标;弼漫性血管内凝血:诊断;作用; Abstract: Objective To explore the clinical value of coagulation test in the diagnosis of DIC. Methods 100 patients with DIC admitted from January 2017 to December 2018 were included in the study, i.e. the study group, and 100 healthy people who came to the hospital at the same time were selected as the control group; both groups received coagulation test, and the results were analyzed and compared. Results Pt, APTT, TT and INR in the study group were higher than those in the control group, while FIB in the study group were lower than those in the control group (P < 0.05); Pt, APTT, TT and Fib in the study group were lower than those in the low coagulation period and fibrinolysis period, while INR was significantly higher than those in the low coagulation period and fibrinolysis period (P < 0.05). Conclusion the clinical value of using coagulation test index to diagnose DIC is high, and it is more effective to evaluate the stage of DIC.
简介:摘要:目的:探讨凝血指标在冠心病诊疗中临床应用的价值。方法:选取 2019年 1月到 2020年 1月在我院心血管病房就诊的 80例冠心病患者,以及本院健康体检者 80例。比较两组凝血指标如 D-二聚体、 Fib、 PT、 APTT的值。结果:经测定冠心病患者组 D-二聚体指标为(
简介:【摘要】 目的: 血液透析体外循环凝血的护理措施。方法:选择 2018 年 4 月—— 2019 年 12 月我院收治的 72 例血液透析患者,分析 体外循环凝血的危害因素,且配合护理干预,观察效果。结果:本组 72 例患者中共 21 例发生 体外循环凝血,发生率 29.16% ( 21/72 ) ;比较护理前后患者的凝血四项 PT 、 APTT 、 TT 与 Fbg ,结果显示,差异显著,有统计学意义( P<0.05 )。结论:血液透析过程中,需加强观察分析,评估 体外循环凝血的危险因素,且配合恰当的护理干预,降低 体外循环凝血发生率,改善预后。
简介:摘要:目的:分析急性脑梗死患者血栓弹力图与凝血功能检查的相关性。方法:选取2020年2月-2020年9月本院收治的90例急性脑梗死患者及65例健康体检者为研究对象,急性脑梗死患者列为观察组,健康体检者列为对照组,两组均行血栓弹力图检测,比较两组血栓弹力图参数[凝血反应时间(R)、血细胞凝集块形成时间(K)、血凝块最大强度(MA)、凝血综合指数(CI)、血细胞凝集块形成速率(a角)]与凝血功能四项[D-二聚体(DD)、血浆凝血酶原时间(PT)、部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB);同时将血栓弹力图参数与凝血功能四项进行相关性分析。结果观察组与对照组受检者的凝血反应时间(R)[(5.32±0.42)minvs(6.43±0.95)min]、血细胞凝集块形成时间(K)[(2.21±0.79)minvs(2.89±0.96)min]比较,观察组明显低于对照组,差异均有统计学意义(P
简介:
简介:【摘要】目的:统计学分析临产孕妇凝血四项及血常规检测的临床价值。方法:选择我院 2018年 10月 -2019年 10月期间收治的 60例临产孕妇作为对照组,选择同一时期收治的 60例非妊娠健康女性作为观察组,由我院同一组检验人员对两组研究对象进行血常规检测(血小板、白细胞计数、红细胞计数、血红蛋白)、凝血四项(凝血活酶时间、凝血酶原时间、凝血酶时间、纤维蛋白原)检测,比较两组血常规检测结果与凝血四项检测结果。结果:观察组与对照组血小板相比较,差异无统计学意义( P>0.05);观察组白细胞计数显著高于对照组,红细胞计数、血红蛋白显著低于对照组,差异具有统计学意义( P<0.05);观察组纤维蛋白原显著高于对照组,凝血活酶时间、凝血酶原时间、凝血酶时间均显著短于对照组,差异具有统计学意义( P<0.05)。结论:对临产孕妇进行凝血四项及血常规检测,可根据检测结果判断临产孕妇贫血情况,有效预防母婴并发症,保证分娩顺利,价值显著。
简介:【摘要】:目的 检测乙型肝炎肝硬化患者的凝血功能,研究其与肝硬化肝损害的相关性。方法 选择我院 2018年 3月至 2019年 9月收治的 46例乙型肝炎肝硬化患者作为观察组,另选取 46例来我院健康体检的健康人群作为对照组,分别检测并比较两组研究对象的凝血酶原时间( PT)、凝血酶时间( TT)、活化部分凝血酶原时间( APTT)、纤维蛋白原( FIB)等凝血功能指标水平。结果 与对照组比较,观察组 PT、 TT、 APTT以及 FIB水平均明显升高,差异有统计学意义( P<0.05)。随着肝功能分级的不断升高,凝血功能各指标水平均明显升高,差异有统计学意义( P<0.05)。结论 乙型肝炎肝硬化患者具有明显的凝血功能障碍 ,容易发生广泛性出血等并发症,监测其变化有助于治疗方案的调整,对判断预后有重要的参考价值。