Aim:TostudytheeffectofEcdysterone(ECR)ontheexpressionofTaufromthecerebralcorticeandhippocampusandbehaviorsinpassiveavoidancereactionandspatialdiscriminationofthemiceinducedbyoverloadaluminumsalt.MethodsFourty-fiveNIHmicewererandomlypidedintofivegroups,thecontrolgroup,themodelgroup,thetreated