摘要
Objective:Toexploretheantitumormechanismsofbifidobacteriaadolescenceinvivo.Methods:Thecontentofextracellularsignalregulatedproteins(ERK)1/2,C-JunN-terminalkinase(JNK),p38,c-fosandc-juninnudemousetransplantedlargebowelcarcinomawasdetectedbyusinglaserconfocalmicroscopy.TheexpressionofNF-kBwasdeterminedbyimmunohistochemistry.Results:Afterthenudemousetransplantedtumorwastreatedwithbifidobacteria,theaveragefluorescentstrengthofERK1/2,JNK,c-fosandc-junwassignificantlylowerthanthatintumorcontrolgroup(P<0.01).Theaveragefluorescentstrengthofp38wasnotobviousdifferenceinthetwogroups(P>0.05).ThepositivecelldensityofNF-kBinlargebowelcarcinomatransplantationtumorsinBifidobacteriuminjectiongroupwasmarkedlylowerthanthatintumorgroup(P<0.01).Conclusion:bifidobacteriaadolescencecouldmarkedlydecreasetheactivityofERK1/2andJNK,theexpressionc-fosandc-jun,andtheactivityofNF-kB.
出版日期
2005年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
