摘要
Cancerisgenerallyregardedastheresultofabnormalgrowthofcells.AccordingtoWorldHealthOrganization,canceristheleadingcauseofmortalityworldwide.Mothernatureprovidesalargesourceofbioactivecompoundswithexcellenttherapeuticefficacy.Numerousphytochemicalsfromnaturehavebeeninvestigatedforanticancerproperties.Inthisreviewarticle,wediscussseveralnaturalcompounds,whichhaveshownanti-canceractivity.Naturalcompoundsinducecellcyclearrest,activateintrinsicandextrinsicapoptosispathways,generateReactiveOxygenSpecies(ROS),anddown-regulateactivatedsignalingpathways,resultingininhibitionofcellproliferation,progressionandmetastasisofcancer.Severalpreclinicalstudieshavesuggestedthatnaturalcompoundscanalsoincreasethesensitivityofresistantcancerstoavailablechemotherapyagents.Furthermore,combiningFDAapprovedanti-cancerdrugswithnaturalcompoundsresultsinimprovedefficacy.Onthebasisoftheseexcitingoutcomesofnaturalcompoundsagainstseveralcancertypes,severalagentshavealreadyadvancedtoclinicaltrials.Inconclusion,preclinicalresultsandclinicaloutcomesagainstcancersuggestpromisinganticancerefficacyofagentsfromnaturalsources.
出版日期
2015年10月20日（中国期刊网平台首次上网日期，不代表论文的发表时间）
