简介:Thispapercontainsadetailed,selfcontainedandmorestreamlinedproofofthel~2decouplingtheoremforhypersurfacesfromthepaperofBourgainandDemeterin2015.TheauthorshopethiswillserveasagoodwarmupforthereadersinterestedinunderstandingtheproofofVinogradov'smeanvaluetheoremfromthepaperofBourgain,DemeterandGuthin2015.
简介:InthispaperitturnsoutthataBanachlatticeXisorderisomorphictol~1(Γ)forsomenonemptysetΓiffitisaSchurspaceandalltheinfinitelydimensional,separableandclosedidealsofXareorderisomorphic.
简介:摘要:组织结构是企业管理存在的基础,是企业管理系统总体框架,是企业经营发展实现战略目标的载体和手段,承载着企业运营过程中各种流程的落地。如果企业的组织结构不能适应内外部环境,不能适应企业文化,不能适应企业战略、人员素质以及企业规模和企业生活周期及技术水平,将难以长久良性的经营和发展下去。本文以L公司组织结构作为研究对象,系统地分析了L公司现行组织结构运营过程中存在的问题及其原因,有针对的提出了取舍部门简化大组织结构、选择矩阵式组织结构优化品牌管理部门、销售大区选择事业部制组织结构提升区域管理水平等组织结构优化方案有效实施的保障措施,更好地适应环境变化、提升组织效率、促进企业健康良性发展。
简介:NineteenL-N-2-hydroxyethylaminoacidsandL-N,N-bis(2-hydroxyethyl)aminoacidswerepreparedfromthereactionofchlorohydrinwithL-alanine,L-valine,L-leucine,L-isoleucine,L-phenylalanine,L-serine,L-thrcunine,L-glutamicacid,L-asparticacidandglycine.L-N,N,N’,N’-tetra(2-hydroxyethyl)cystinewaspreparedbythereactionofL-cystinewithchlorohydrin.
简介:AbstractObjective:To investigate the relationship between the concentration of L-carnitine in semen and sperm parameters and investigate the epigenetic profile in sperm cell after L-carnitine usage.Methods:From February 2017 to February 2018, 46 semen samples from asthenospermic males and 41 semen samples from healthy donors were acquired. Motility parameters were assessed using computer-assisted sperm analysis (CASA, n = 78) and the DNA fragmentation index (DFI) was evaluated through flow cytometry (n = 86), %DFI = % cells outside main population. Other oxidative stress markers, such as reactive oxygen species (ROS) levels (n = 86) and the mitochondria DNA copy numbers, were detected (n = 78). The concentration of L-carnitine and acetyl-L-carnitine was detected (n = 82), and methylation was analyzed (n = 30). After that, we collected 13 fresh semen samples from asthenospermic males and 23 fresh semen samples from healthy donors. These samples were used in a freeze-thaw model that was used to determine whether adding L-carnitine could change sperm progressive motility (n = 23), apoptosis index (n = 9), and methylation analysis (n = 7). In total, we have done 13 asthenospermia samples for Western blot, and except for the poor Western result, we analyzed 6 samples for H3K9ac detection, 7 samples for H3K9m3 and H3K27m3 detection, and immunofluorescence (n = 3). Finally, we had recruited 30 volunteers, and they were given oral administration of L-carnitine for 3 months and then collected semen samples at different time points for methylation analysis.Results:The concentration of acetyl-L-carnitine is negatively correlated with the %DFI value (r2 = 0.1090; P = 0.0026), and the concentration of acetyl-L-carnitine is positively correlated with sperm forward motility (r2 = 0.0543; P = 0.0458) and ROS (r2 = 0.1854; P < 0.0001), and the acetyl-L-carnitine level is negatively correlated with %DFI in asthenospermia (r2 = 0.1701; P = 0.0066), and the level of acetyl-L-carnitine in asthenospermic semen is significantly lower than the normal group (P = 0.0419). In addition, this study indicates that adding L-carnitine significantly improved sperm motility (P = 0.0325) and reduced sperm apoptosis (P = 0.0032). Importantly, Western blotting (P = 0.0429) and immunofluorescence staining results showed that the addition of L-carnitine reduced H3K9Me3 methylation level in sperm, respectively. Furthermore, semen samples from asthenospermic patients had reduced methylation levels in a specific region (16thP= 0.0003; 17thP= 0.0016) of the brain-derived neurotrophic factor (BDNF) promoter. The 16th methylation decreased with age (r2 = 0.1564; P = 0.0306), and the 17th methylation was decreased after treatment with L-carnitine for 28 days (P = 0.0341).Conclusion:L-carnitine can reduce the %DFI and also affect the methylation of the histone modification marker in sperm as a possible epigenetic regulator.
简介:GivenacontinuousfunctionfdefinedontheunitcubeofRnandaconvexfunctiont,t(0)-0,t(x)>0,forx>0,weprovethatthesetofbestLt-approximationsbymonotonefunctionshasexactlyoneelementft,whichisalsoacontinuousfunction.Moreoverifthefamilyofconvexfunctions{t}t>0convergesuniformlyoncompactsetstoafunction0,thenthebestapproximationft→f0uniformly,ast→0,wherefoisthebestapproximationoffwithintheOrliczspaceL0Thebestapproxima-tions{ft}areobtainedaswellasminimizingintegralsortheLuxemburgnorm
简介:让Sq-1,q≥2,联合起来的范围的表面在欧几里德几何学的spaceRq,f(x)∈Lp(Sq-1),f(x)≥0,f吗?0,1≤p≤+∞。然后,它在现在的纸被证明有顺序≤N和经常的C>的球形的泛音PN(x)0以便‖f-1/P_N‖L_p≤Cω(f,N~(-1))Lp,在哪儿ω(f,吗δ)Lp=sup_(0