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简介：Aim:Toinvestigatetheeffectofhome-basedcardiacrehabilitationonfunctionalcapacity,healthbehavior,andriskfactorsinpatientswithacutecoronarysyndromeinChina.Methods:Eightypatientswithacutecoronarysyndromewereenrolledinthisprospectiverandomizedcontrolledstudy.Patientsinthecardiacrehabilitationgroup(n=52)receivedhome-basedcardiacrehabilitationwithaheartmanualandahomeexercisevideofor3monthsandpatientsinthecontrolgroup(n=28)receivedonlyroutinesecondaryprevention.The6-minwalkdistance,laboratorytestresults,healthybehavior(questionnaire),qualityoflife(12-itemShortFormHealthSurvey),anxiety(7-itemGeneralizedAnxietyDisorderQuestionnaire),anddepression(9-itemPatientHealthQuestionnaire)wereevaluatedatthebeginningandaftertreatmentfor3months.Results:Comparedwithbaselinedata,52patientswhoparticipatedincardiacrehabilitationhadlonger6-minwalkdistance(515.26±113.74mvs0.445.30±97.92m,P<0.0002),higherproportionsof“alwaysexercise”(78.26%vs.28%,P<0.05),“alwayslimitfoodwithsugar”(65.22%vs12%,P<0.05),“alwayseatfruits200–400geveryday”(82.61%vs.4%,P<0.05).and“alwayseatvegetables300–500geveryday”(21.74%vs.12%,P<0.06)aftertreatmentfor3months.Thelow-densitylipoproteincholesterolcontrolrate(52.17%vs.28%,P<0.05)andthesystolicbloodpressurecontrolrate(100%vs.68%,P<0.05)werealsosignificantlyincreasedaftertreatmentfor3monthsinthecardiacrehabilitationgroup.Nosignificantincreasewasfoundinthecontrolgroupaftertreatmentfor3months.Nocardiac-eventrelatedtohomeexercisewasreportedinbothgroups.Conclusion:Home-basedcardiacrehabilitationisafeasibleandavailablecardiacrehabilitationmodeinChina.

简介：AbstractBackground:Deep brain stimulation (DBS) has proved effective for Parkinson’s disease (PD), but the identification of stimulation parameters relies on doctors’ subjective judgment on patient behavior.Methods:Five PD patients performed 10-meter walking tasks under different brain stimulation frequencies. During walking tests, a wearable functional near-infrared spectroscopy (fNIRS) system was used to measure the concentration change of oxygenated hemoglobin (ΔHbO2) in prefrontal cortex, parietal lobe and occipital lobe. Brain functional connectivity and global efficiency were calculated to quantify the brain activities.Results:We discovered that both the global and regional brain efficiency of all patients varied with stimulation parameters, and the DBS pattern enabling the highest brain efficiency was optimal for each patient, in accordance with the clinical assessments and DBS treatment decision made by the doctors.Conclusions:Task fNIRS assessments and brain functional connectivity analysis promise a quantified and objective solution for patient-specific optimization of DBS treatment.Trial registration:Name: Accurate treatment under the multidisciplinary cooperative diagnosis and treatment model of Parkinson’s disease. Registration number is ChiCTR1900022715. Date of registration is April 23, 2019.

简介：Heterogeneousnuclearribonucleoproteins(hnRNPs)arespliceosomalmacromolecularassemblagesandthusactivelyparticipateinpre-mRNAmetabolism.Theyarecomposedofevolutionarilyconservedandtandemlyrepeatedmotifs,wherebothRNA-bindingandprotein-proteinrecognitionoccurtoachievecellularactivities.Byyetunknownmechanisms,theseribonucleoprotein(RNP)particlesaretargetedbyautoantibodiesandhenceplaysignificantroleinavarietyofhumansystemicautoimmunediseases.Thisfeaturemakesthemimportantprognosticmarkersintermsofmolecularepidemiologyandpathogenesisofautoimmunity.SinceRNPdomainisoneofthemostconservedandwidespreadscaffolds,evolutionalysesoftheseRNA-bindingdomainscanprovidefurthercluesondisease-specificepitopeformation.ThestudypresentedhereinrepresentsasequencecomparisonofRNA-recognitionregionsofrecentlyclonedandcharacterizedhumanhnRNPA3withthoseofotherrelevanthnRNPA/B-typeproteins.Theirimplicationsinhumanautoimmunityareparticularlyemphasized.

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简介：Thegeometricalstructuresof2-(2-hydroxyphenyl)pyridine(PP)anditsprotonationstateswereoptimizedbymeansoftheB3LYP/6-31G(d)method.Foralltheselectedsystems,theexistenceofH-bondisinfavorofthestabilityofthesystems.Onthebasisoftheoptimizedgeometricalstructures,theirelectronicspectrumpropertieswerestudiedbytime-dependentdensityfunctionaltheory(TD-DFT)methosdviaahybridfunctionofB3LYPand6-31G(d)basisset.TheTD-DFTcalculationresultpredictstheabsorptionspectrumofPPat324nm(3.82eV),whichisinverygoodagreementwiththeexperimentalvalueof322nm(3.85eV)determinedinsolventchloroform.TheabsorptionspectraofthetwoprotonationstatesbothexertaredshiftinvariouspHmedia.

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简介：Thecurrentstudydemonstratedthatinjuryofthespinalcordlateralfuniculusoccursinlivercirrhosis.Thisstudysoughttocomparethemorphologyofthethoracicandlumbarcord,theexpressionoffunctionalproteins,andchangesinvesselsbetweenlivercirrhosisandnon-cirrhosiscorpses.Resultsshowedthatinthelivercirrhosisgroup,thehepaticveinexpanded,thegastrointestinaltractwasfullofcoagulatedblood,blood-stasiswaseasilyseenintheveniplexofthevertebralcanalandthelumbarspinalcord,andthecellbodiesoftheanteriorhorninthethoracicandlumbarcordweresmallerthanthoseinnon-cirrhosiscorpses.Inaddition,nervecellsshrank,Nisslbodieswereconcentratedwithobscurednuclei,andneurofilamentandsynapsincontainingcellbodiesoftheanteriorhornandwhitematterdecreasedinthelivercirrhosisgroup.Theseexperimentalfindingsindicatethatabnormalcirculationofthespinalcord,resultingfromhemodynamicchangeofcirrhoticportalhypertension,maybethemostsignificantcauseofhepaticmyelopathy.

简介：Acupunctureiswidelyusedtotreatfunctionaldyspepsiawithsatisfactoryoutcomes.CombinationoftheHeandMuacupointsiscommonlyusedandhasasynergisticeffectonfunctionaldyspepsia;however,itsunderlyingmechanismsremainunclear.Therefore,arandomizedcontrolledparallelclinicaltrialiscurrentlyunderwayatChengduUniversityofTraditionalChineseMedicine,China.ThistrialisdesignedtoexploretheefficacyofandcentralresponsestotheHe-Mupointcombinationinpatientswithfunctionaldyspepsiausingfunctionalmagneticresonanceimaging.Atotalof105patientswithfunctionaldyspepsiawillbeallocatedinto3groups:thelow-Hepointgroup(puncturingatZusanli(ST36)),Mupointgroup(puncturingatZhongwan(CV12)),andHe-Mupointcombinationgroup(puncturingatST36andCV12).Everyparticipantwillreceive20sessionsofmanualacupuncturefor4weeks.Theneedleswillbeinsertedperpendicularlytoadepthof1to2cun.Theangleofrotationandtwistingwillrangefrom90to180degrees,whileliftingandthrustingwillrangefrom0.3to0.5cm.Thevariousmanipulationswillbeperformed60to90timesperminute.Theneedleswillremaininplacefor30minutes,duringwhichmanipulationwillbeappliedevery10minutes.Magneticresonanceimagingwillbeperformedbeforeandafter20sessionsofacupuncture.TheprimaryoutcomeissymptomimprovementaccordingtotheChineseversionoftheNepeanDyspepsiaIndex.SecondaryoutcomesincludetheLeedsdyspepsiaquestionnaire,Self-RatingAnxietyScale,Self-RatingDepressionScale,BeckAnxietyInventory,BeckDepressionInventory,andvisualanaloguescalescoresbeforeandafter10and20sessionsofacupuncture.Needlesensationandadverseeventswillbeusedtoassessthetherapeuticeffects.ThisstudywillpromotemorewidespreadawarenessofthebenefitsofacupointcombinationintheclinicalsettingandprovideafurtherexplanationoftheneuromechanismbywhichacupunctureattheHe-Mupointcombinationforfunctio

简介：与时间依赖者本地人密度近似的框架，对簇的光反应的有效描述被用来学习Na_2和Na_4簇的the.photo吸收十字节。我们的计算结果在对实验的好同意，这被显示出。另外，我们为Na_4簇的计算光谱比GW吸收光谱在对实验的更好的同意。

简介：WeuseamodifiedBecke-JohnsonexchangeplusalocaldensityapproximationcorrelationpotentialwithinthedensityfunctionaltheorytoinvestigatetheelectronicstructuresofHg1-xCdxTeandIn1-xGaxAswithxbeing0,0.25,0.5,0.75,and1.Forbothofthetwoseries,ourcalculatedenergygapsanddielectricfunctions（realpartε1andimaginarypartε2）areinagreementwiththecorrespondingexperimentalresultswithxbeingbetween0and1.Thecalculatedzero-frequencyrefractiveindexvariesgreatlywithxforHg1-xCdxTe,butchangeslittlewithxforIn1-xGaxAs,whichisconsistentwiththerealpartsoftheirdielectricfunctions.Therefore,thisnewapproachissatisfactorytodescribetheelectronicstructuresandtheopticalpropertiesofthesemiconductors.

简介：Refractorymaterialsaresubjectedtomechanicalandchemicalloadsduringapplication,whichrespectivelyleadtofractureandcorrosion.Theunderstandingofthemechanicalfractureandthemicrostructuralmodificationafterprogressivethermalshocksisnecessaryforthesuitabledesignofhighperformancerefractorymaterials.Thefractureprocesszonecanbedividedintotwoareas,wheredifferenttougheningmechanismsarelikelytotakeplace:thecracktipandthefollowingprocessregioncalledwakeregion.Inthisstudy,theemphasisislaidonthemicrostructuralmechanismsoccurringinthewakeregionofthecrackandthecracktip.Therefore,functionalaggregates,namelyfusedeutecticaggregatesofAl2O3-ZrO2-SiO2andAl2O3-ZrO2,andandalusite,areaddedtoamodelhighaluminacastableformulationbasedontabularalumina.Thediscrepancyinthermalbehaviorbetweenaggregatesandmatrixaswellasphasetransformationsuchasmulliteformationfavorfurtherthenucleationofmicrocracksthatreducethestressfieldatthelevelofthecracktip.Twodifferentgrainfractionsoftabularalumina(0.2-0.6mmor2.24-3.00mm)aresubstitutedbythesefunctionalaggregates.Aftersinteringat1500℃for6h,thesamplesarequenchedupto10timesinairwithoutpressurefrom950℃toroomtemperature.Theresultingelasticpropertiesareexaminedaftereachthermalshockcycle,aswellastheresidualbendingstrengthafter0,1,3,5,7and10thermalshocks.TheseresultsarecorrelatedwithScanningElectronMicroscopyanalysesafterthedifferentthermalshockcycles.

简介：流行性感冒A病毒(H1N1)，人的地方性的紧张的一个基因分类，鸟并且猪流感，穿过种类障碍到人并且显然获得了人的能力到人的传播。因为NS1蛋白质禁止抗病毒的干扰素/生产，H5N1子类型的一些紧张是高度剧毒的。另一蛋白质NS2调停到通过出口的细胞质的从原子核的病毒的ribonucleoprotein的出口信号。在这份报纸，我们学习了H1N1子类型的这些蛋白质的结构功能关系并且决定了他们的致病力的原因。我们的结果证明非保守的变化稍微稳定了或使动摇NS1或NS1-dsRNA建筑群的结构的域，稍微因此增加了或减少NS1蛋白质并且因而的函数提高了或减少H1N1病毒的致病力。不同紧张的NS2蛋白质在不同领域带了非保守的变化，导致功能的细微损失。这些变化稍微减少了病毒的致病力。因此，结果证实这些病毒的蛋白质的结构功能关系。

简介：AbstractBackground:Resting-state functional magnetic resonance imaging (rs-fMRI) is a promising method for the study of brain function. Typically, rs-fMRI is performed on anesthetized animals. Although different functional connectivity (FC) in various anesthetics on whole brain have been studied, few studies have focused on different FC in the aged brain. Here, we measured FC under three commonly used anesthesia methods and analyzed data to determine if the FC in whole brain analysis were similar among groups.Methods:Twenty-four male aged Wistar rats were randomly divided into three groups (n = 8 in each group). Anesthesia was performed under either isoflurane (ISO), combined ISO + dexmedetomidine (DEX) or α-chloralose (AC) according to the groups. Data of rs-fMRI was analyzed by FC in a voxel-wise way. Differences in the FC maps between the groups were analyzed by one-way analysis of variance and post hoc two-sample t tests.Results:Compared with ISO + DEX anesthesia, ISO anesthesia caused increased FC in posterior brain and decreased FC in the middle brain of the aged rat. AC anesthesia caused global suppression as no increase in FC was observed.Conclusion:ISO could be used as a substitute for ISO + DEX in rat default mode network studies if the left temporal association cortex is not considered important.

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简介：Theuniformsurfaceion-imprintedresinsforZn2+astheimprintingguestwerepreparedbyemulsifier-freeemulsionpolymerizationutilizingallyphenylhydrogenphosphateasafunctionalcomonomer.TheZn2+-imprintedresinadsorbedZn2+muchmoreeffectivelythandidtheunimprintedone.Theselectivefeatureofthesurfaceimprintedresinstothetemplateionswasdemonstrated.

简介：人的造血作用用控制干细胞区别的技术被评估，二维的胶化基于电气泳动的proteomics，和功能的基因组学。我们提供神经胶质成熟因素鲸鱼群妈(GMFG)是cytokine应答的蛋白质在的第一份报告导致erythropoietin并且刺激导致因素的造血的系开发的granulocyte殖民地。从全球功能的基因组学分析的结果显示GMFG拥有几个另外的特征：造血的织物特定的基因表示，与高分数的造血作用特定的抄写因素集中的一个倡导者，和有一个原始血/免疫者系统的可能的分子的coevolution。根据我们的调查结果，我们假设那GMFG是可以调停的造血特定的蛋白质人的造血的干细胞的pluripotentiality和系承诺。

简介：在这研究，被尝试了从他们的氨基酸序列预言克否定的细菌的蛋白质的主要功能。使用训练并且测试的数据集由670非冗余的克否定的细菌的蛋白质(255细胞的过程，60个信息分子，285新陈代谢，和70个毒力因素)组成。首先，我们开发了使用氨基酸和dipeptide作文的一个基于SVM的方法并且分别地完成了52.39%和47.01%的全面精确性。我们基于tetrapeptides，我们在识别了显著地在蛋白质的一个班上发现的唯一的tetrapeptides为蛋白质的分类介绍了一个新概念。这些tetrapeptides作为输入特征被使用预言蛋白质的功能并且完成了68.66%的全面精确性。我们也开发了tetrapeptide信息与氨基酸作文在被使用并且完成了70.75%的全面精确性的一个混合方法。五倍的生气确认被用来评估这些方法的表演。网服务器VICMpred为预言克否定的细菌的蛋白质(http://www.imtech.res.in/raghava/vicmpred/)的函数被开发了。

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简介：AbstractBackground:Follistatin-like 1 (FSTL1) plays both pro-inflammatory and anti-inflammatory roles in the inflammatory processes. We investigated whether serum FSTL1 could predict the current anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV)-specific indices.Methods:We randomly selected 74 patients with AAV from a prospective and observational cohort of Korean patients with AAV. Clinical and laboratory data and AAV-specific indices were recorded. FSTL1 concentration was determined using the stored sera. The lowest tertile of the short-form 36-item health survey (SF-36) was defined as the current low SF-36. The cutoffs of serum FSTL1 for the current low SF-36 physical component summary (PCS) and SF-36 mental component summary (MCS) were extrapolated by the receiver operator characteristic curve.Results:The median age was 62.5 years (55.4% were women). Serum FSTL1 was significantly correlated with SF-36 PCS (r = -0.374), SF-36 MCS (r = -0.377), and C-reactive protein (CRP) (r = 0.307), but not with Birmingham vasculitis activity score (BVAS). In the multivariable linear regression analyses, BVAS, CRP, and serum FSTL1 were independently associated with the current SF-36 PCS (β = -0.255, β = -0.430, and β = -0.266, respectively) and the current SF-36 MCS (β = -0.234, β=-0.229, and β= -0.296, respectively). Patients with serum FSTL1 ≥779.8 pg/mL and those with serum FSTL1 ≥841.6 pg/mL exhibited a significantly higher risk of having the current low SF-36 PCS and SF-36 MCS than those without (relative risk 7.583 and 6.200, respectively).Conclusion:Serum FSTL1 could predict the current functional status in AAV patients.