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简介：<正>Chinapromisedtoadopt"thestrictest"environmentandenergypoliciesonDecember25asithaslaggedbehindintermsoffourbindingenvironmentaltar-getssetfor2015,XinhuaNewsAgencyreported.Thefourtargetsareforenergyintensity,carbondioxideemissions,rationalizationofenergyconsumptionandnitrogenoxideemissions,according

简介：Weputforwardthecredittargetssequencessetandorderingstructureofcredittargetssequencesandthedominancestructureincredittargetssequencesset.Wealsogiveamodeltoevaluatecustomer'screditbythedeviation.

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简介：AbstractImmunotherapy has become the mainstay for lung cancer treatment, providing sustained therapeutic responses and improved prognosis compared with those obtained with surgery, chemotherapy, radiotherapy, and targeted therapy. It has the potential for anti-tumor treatment and killing tumor cells by activating human immunity and has moved the targets of anti-cancer therapy from malignant tumor cells to immune cell subsets. Two kinds of immune checkpoints, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1), are the main targets of current immunotherapy in lung cancer. Despite the successful outcomes achieved by immune checkpoint inhibitors, a small portion of lung cancer patients remain unresponsive to checkpoint immunotherapy or may ultimately become resistant to these agents as a result of the complex immune modulatory network in the tumor microenvironment. Therefore, it is imperative to exploit novel immunotherapy targets to further expand the proportion of patients benefiting from immunotherapy. This review summarizes the molecular features, biological function, and clinical significance of several novel checkpoints that have important roles in lung cancer immune responses beyond the CTLA-4 and PD-1/PD-L1 axes, including the markers of co-inhibitory and co-stimulatory T lymphocyte pathways and inhibitory markers of macrophages and natural killer cells.

简介：Whenthereturnscomefromtwoormoreunresolvedtargets(thesignalsarenotresolvedinthefrequencyortimedomains)inamonopulseradarsystem,thedirection-of-arrival(DOA)estimateindicatedbythemonopulseratioisnotthetrueinformationofthetrackedtarget.Thenthetrackingsystemsisinfluenced.Anapproachhasbeenproposedtodetectwhetherthereturnscomefromasingletargetortwounresolvedtargets.Theaboveapproachisextendedfromtwotothreeunresolvedtargets.Thesimulationindicatesthatthedetectionprobabilityunderthethreeunresolvedtargetsisnotsuretoexceedthedetectionprobabilityunderthetwounresolvedtargets.

简介：AbstractPancreatic cancer is one of the most aggressive malignancies. The poor prognosis of pancreatic cancer patients is mainly attributed to low diagnostic rate at the early stage, highly aggressive nature coupled with the inadequate efficacy of current chemotherapeutic regimens. Novel therapeutic strategies are urgently needed for pancreatic cancer. MicroRNAs (miRNAs) play an important regulatory role in key processes of cancer development. The aberrant expression of miRNAs is often involved in the initiation, progression, and metastasis of pancreatic cancer. The discovery of tumor suppressor miRNAs provides prospects for the development of a novel treatment strategy for pancreatic cancer. We reviewed recent progress on the understanding of the role of miRNAs in pancreatic cancer, highlighted the efficient application of miRNAs-based therapies for pancreatic cancer in animal models and clinical trials, and proposed future prospects. This review focuses on the promise of integrating miRNAs into the treatment of pancreatic cancer and provides guidance for the development of precision medicine for pancreatic cancer.

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简介：Whentheclassicalconstantfalse-alarmrate(CFAR)combinedwithfuzzyC-means(FCM)algorithmisappliedtotargetdetectioninsyntheticapertureradar(SAR)imageswithcomplexbackground,CFARrequiresblock-by-blockestimationofcluttermodelsandFCMclusteringconvergestolocaloptimum.Toaddresstheseproblems,thispaperpro-posesanewdetectionalgorithm:knowledge-basedcombinedwithimprovedgeneticalgorithm-fuzzyC-means(GA-FCM)algorithm.Firstly,thealgorithmtakestargetregion’smaximumandaverageintensity,area,lengthoflongaxisandlong-to-shortaxisratiooftheexternalellipseasfactorswhichinfluencethetargetappearingprobability.Theknowledge-baseddetectionalgorithmcanproducepreprocessresultswithouttheneedofestimationofcluttermodelsasCFARdoes.AfterwardtheGA-FCMalgorithmisimprovedtoclusterpre-processresults.IthasadvantagesofincorporatingglobaloptimizingabilityofGAandlocaloptimizingabilityofFCM,whichwillfurthereliminatefalsealarmsandgetbetterresults.TheeffectivenessoftheproposedtechniqueisexperimentallyvalidatedwithrealSARimages.

简介：Highharmonicgenerationingasjetswasinvestigatedindifferentgasesuptomorethan14barbackingpressure.TheobservationofincreaseofharmonicintensitywithincreasingpressureandlaserintensityshowsevidenceofthepresenceofclustersinXewithanincreasedefficiencycomparedwithHe,whereasArisanintermediatecaseforwhichclusterswillstarttodominateaboveacertainbackingpressure.Spectralinvestigationsgiveevidencefortunableharmonicgenerationinabroadspectralrange.Aspectralshiftofoppositesignaturecausedbythefreeelectronsinthefocalvolumeandthenanoplasmasinsidetheclusterwasobserved.

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简介：生物信息的途径补充了试验性的努力到inventorize植物miRNA目标。我们执行了产生通常认为的miRNA的一张全面的表的transcriptome指向的米饭(Oryzasativa)的全球计算分析。我们的预言(684个唯一的抄本)证明米饭miRNAs调停包括抄写(41%)的多样的功能的规定，催化作用(28%)，绑定(18%)，和transporter活动(11%)。在预言的目标之中，61.7%点击在编码区域，将近72%目标让独居的miRNA撞击。学习预言了通常认为地调整象压力反应，催化作用，和绑定一样的函数的34miRNAs的超过70个新奇目标。非常，目标的一半(55%)在O之间被保存，这被观察。sativaindica和O。sativa装饰用的梨树。31个miRNA家庭的成员被发现拥有在米饭之间并且至少的保存目标另外的草家庭成员之一。大约44%唯一的目标在二个不一样的miRNA预言算法之间是普通的。跨种类的保存和算法的一致的如此的程度在在这研究预言的米饭miRNA目标的表授与信心。

简介：Targetshavebeendevelopedtomeasuresupersonicradiationtransportinaerogelfoamsusingabsorptionspectroscopy.Thetargetconsistsofanaerogelfoamuniformlydopedwitheithertitaniumorscandiuminsertedintoanundopedaerogelfoampackage.Thiscreatesalocalizeddopedfoamregiontoprovidespatialresolutionforthemeasurement.Developmentandcharacterizationofthefoamsisakeychallengeinadditiontomachiningandassemblingthetwofoamssotheymatewithoutgaps.Thefoampackageisinsertedintoaberylliumsleeveandmountedonagoldhohlraum.Thetargetismountedtoaholdercreatedusingadditivemanufacturingandmountedonastalk.Themanufacturingofthecomponents,alongwithassemblyandmetrologyofthetargetaredescribedhere.

简介：为了开发一个双人脚踏车弹头，那能有效地破坏具体目标，这篇论文借助于实验与不同的锥角度和班机材料探索塑造的费用的穿入表演进具体目标。穿入过程和由塑造的费用和动能射弹的具体目标的破坏机制被分析并且比较。试验性的结果建议运动精力充沛的射弹和塑造的充电能够破坏损坏的具体目标，而是大小是不同的。与动能射弹相比，塑造的费用有穿入的更多的重要效果进目标，并且引起很大的spalling区域。因此，塑造的费用对双人脚踏车弹头的第一阶段的充电相当合适。当洞直径变得更大时，随塑造的费用班机锥角度的增加，穿入的深度逐渐地减少，这也被发现。有铜班机的穿入深度比铝班机大，但是洞直径相对更小，并且有钢班机的塑造的起诉在上述二诉讼之间。有100°的一个锥角度的塑造的费用能形成喷气射弹费用(JPC)。与JPC，有具体目标上的最佳深度和直径的一个洞能被形成，它保证秒阶段弹头顺利渗透进洞并且在最佳深度爆炸在具体目标完成破坏的需要的水平。

简介：Thispaperpresentsanewmethodtocontrolthepositionofamicro-columnsnowtarget.Thistargetenablesthemeasurementofthemeanelectrondensityofthepre-plasmacreatedbyapre-pulsewithdifferenttimedelays.Thisresearchwillallowabetterunderstandingofthegenerationoffastprotonsfromtheinteractionbetweenastructuredpre-plasmaandahighintensitylaser.

简介：Inertialconfinementfusiontargetsarecomplexsystemsdesignedtoallowfinecontroloftemperatureandpressureformakingprecisesphericalicelayersofhydrogenisotopesatcryogenictemperatures.Wediscussthevarioustechnicalconsiderationsforamaximumleakratebasedonheatloadconsiderations.Thismaximumflowrateturnsouttobe5×10~(-6)standardccpersecond,whichcanbecausedbyanorificelessthanhalfamicronindiameter.Thismakestheidentificationofthelocationandresolutionoftheleakasignificantchallenge.Toillustratethis,weshowcaseoneexampleofapeculiarfailuremodethatappearedsuddenlybutpersistedwherebytargetproductionyieldwasseverelylowered.Identificationoftheleaksourceandtherootcauserequiresverycarefulanalysisofmultiplethermomechanicalaspectstoensurethattheendsolutionisindeedtherightremedyandisrobust.

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简介：Withoutassumptionsmadeonmotionstatesofmissileandtarget,anextendeddifferentialgeometricguidancelawisderived.Throughintroducingalineofsightrotationcoordinatesystem,thederivationissimplifiedandhasmoreexplicitphysicalsignificances.Theextendedlawistheoreticallyapplicabletoanyengagementscenarios.Then,onbasisoftheextendedlaw,amodifiedoneisdesignedwithouttherequirementoftargetaccelerationandanapproachisproposedtodeterminingtheapplieddirectionofcommandedmissileacceleration.Qualitativeanalysisiscarriedouttostudythecaptureperformanceandacriterionforcaptureisgiven.Simulationresultsindicatethetwolawsareeffectiveandmakeupthedeficiencythatpureproportionalnavigationsuitableforendoatmosphericinterceptionscannotdealwithhigh-speedmaneuveringtargets.Furthermore,thecorrectnessofthecriterionisvalidated.

简介：Thepurposeofthispaperistodevelopahighspeeddetectionschemeformovingand/orstationarypointtargetsinamultitargetenvironmentasregisteredinanIRimagesequence.Aniterativeapproximate3-Dlinesearchingalgorithmbaseduponthegeometricrepresentationoflines(fornon-maneuveringtargetsinspace)ina3-Dspaceisderived.Theconvergencyofthealgorithmisproved.Ananalysisisperformedofthetheoreticaldetectionperformanceofthealgorithm.ThestatisticalexperimentresultsshowhigheffectivenessandcomputationalefficiencyofthealgorithminthecaseoflowSNR.Theideamaybeemployedtosatisfythereal-timeprocessingrequirementofanIRsystem.

简介：一个鱼雷的特征“s有多重目标的声学的homing轨道被学习。鱼雷运动的微分方程基于水动力学被介绍。第四个顺序Runge-Kutta方法被用来解决这些方程。源于声纳方程并且敏捷“s法律，一简单虚拟在水下声学的环境为模仿鱼雷homing过程被建立。牛顿迭代法被用来推测homing变化，光线跟踪被片接近明智的线，它由温度，压力，和咸度收进一个给定的海区域进考虑失真原因。某声学的战争设备的影响在某些情形扰乱鱼雷homing过程包括圈套andjammers，也在模拟被考虑。相对目标鉴定逻辑和homing控制法律被介绍。相等的考虑在研究期间被给要求ofreal-timeactivity以及精确性。最后，一个实际鱼雷homing轨道模拟节目被开发并且适用于某些工程。