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简介：ObjectivesEndothelialdysfunctionistheearliestmarkerforatherosclerosisandplayskeyroleinthepathogenesisofcardiovasculardiseases.Thepresentstudywasperformedtoevaluateeffectofagingonarterialelasticitybyusingpulsewaveformanalysisandinvestigatewhetherthechangesinarterialelasticitycanbeusedasanon-invasivemeasureforearlydetectionofendothelialdysfunction.MethodsUsingmodifiedWindkesselmodelofthecirculationandpulsewaveformanalysis,C1largearteryandC2smallarteryelasticityindicesof204normalhealthysubjects(age15-80years)weremeasured.Amongthemtwenty-fourmalehealthysubjectsweredividedintoboththeyoung(age20-30years,n=12)andelderly(age60-70years,n=12)groups.Wedeliveredacethycholine(Ach),anendotheliumdependentvasodilator,andsodiumnitroprusside(SNP),anendothelium-independentvasodilator,todermalvesselsoftheforearmusingiontophoresis,respectively,andmeasuredbasalandpeakbloodflowusinglaserdopplerfluximetry.ResultsC1largearteryandC2smallarteryelasticityindiceswerereducedwithadvancingage.C1largearteryandC2smallarteryelasticityindiceswerenegativelycorrelatedwithage(r=-0.628,p＜0.001;r=-0.595,p＜0.001).Basalbloodflowwassimilarbetweentheyoungandelderlygroups(14.58±3.4vs13.52±3.41PU,p=NS).PeakbloodflowinducedbyAchwassignificantlyreducedintheelderlygroupcomparedwiththeyounggroup(83.4±11.9vs93.75±10.87PU,p＜0.05).However,peakbloodflowinducedbySNPwassimilarinthetwogroups(119.17±16.76vs128.33±21.29PU,p=NS).Ach-inducedpeakbloodflowcorrelatedpositivelywithC1largearteryandC2smallarteryelasticityindices(r=0.56,p＜0.01;r=0.53,p＜0.01).ConclusionsAdvancingageleadstoimpairedarteryelasticityandendothelialdysfunction.Reducedarterialelasticityis,inparallel,associatedwithdiminishedendothelium-dependentvasodilation.Itisconcludedthata

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简介：AbstractFor the detection of steatosis, quantitative ultrasound imaging techniques have achieved great progress in past years. Magnetic resonance imaging proton density fat fraction is currently the most accurate test to detect hepatic steatosis. Some blood biomarkers correlate with non-alcoholic steatohepatitis, but the accuracy is modest. Regarding liver fibrosis, liver stiffness measurement by transient elastography (TE) has high accuracy and is widely used across the world. Magnetic resonance elastography is marginally better than TE but is limited by its cost and availability. Several blood biomarkers of fibrosis have been used in clinical trials and hold promise for selecting patients for treatment and monitoring treatment response. This article reviews new developments in the non-invasive assessment of non-alcoholic fatty liver disease (NAFLD). Accumulating evidence suggests that various non-invasive tests can be used to diagnose NAFLD, assess its severity, and predict the prognosis. Further studies are needed to determine the role of the tests as monitoring tools. We cannot overemphasize the importance of context in selecting appropriate tests.

简介：Thispaperinvestigatesthemathematicfeaturesofnon-linearmodelsanddiscussestheprocessingwayofnon-linearfactorswhichcontributestothenon-linearityofanonlinearmodel.Onthebasisoftheerrordefinition,thispaperputsforwardanewadjustmentcriterion,SGPE.Last,thispaperinvestigatesthesolutionofanon-linearregressionmodelinthenon-linearmodelspaceandmakesthecomparisonbetweentheestimatedvaluesinnon-linearmodelspaceandthoseinlinearmodelspace.

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简介：China’sCrudeMagnesiumOutputDuringJanuary-FebruaryAccordingtothestatisticsofNonferrousMetalsAssociationofChina,China’soutputofcrudemagne-

简介：Anumericalanalysisofnon-Newtonianfluidflowinnon-planararterywithbifurcationwasperformedbyusingafiniteelementmethodtosolvethethree-dimensionalNavier-Stokesequationscoupledwiththenon-Newtonianconstitutivemodels,includingCarreau,CrossandBinghammodels.Theobjectiveofthisstudyistoinvestigatetheeffectsofthenon-Newtonianpropertiesofbloodaswellascurvatureandout-of-planegeometryinthenon-planardaughtervesselsonthevelocitydistributionandwallshearstress.Theresultsofthisstudysupporttheviewthatthenon-planarityofbloodvesselsandthenon-Newtonianpropertiesofbloodareofimportantinhemodynamicsandplayasignificantroleinvascularbiologyandpathophysiology.

简介：Bacterialflagellarfilamentcanundergoastress-inducedpolymorphicphasetransitioninbothvitroandvivoenvironments.Thefilamenthas12differenthelicalforms(phases)characterizedbydifferentpitchlengthsandhelixradii.Whensubjectedtothefrictionalforceofflowingfluid,thefilamentchangesbetweenaleft-handednormalphaseandaright-handedsemi-coiledphaseviaphasenucleationandgrowth.Thispaperdevelopsnon-localfiniteelementmethod(FEM)tosimulatethephasetransitionunderad...

简介：SeveralextensionsofthelogicprogramminglanguagePrologtononHornclausesusecaseanalysistohandlenon-Hornclauses.Inthispaper,analyticalandempriricalevidencesarepresentedtoshowthat,bymakingasetofclausesless'non-Horn'usingpredicatedrenaming.theperformanceofthesecase-analysisbasedprocedurescanbeimprovedsignificantly.Inaddition,thepaperalsoinvestigatedtheproblemofefficeientlyconstructingapredicaterenamingthatreducesthedegreeof'non-Hornness'ofaclausesetmaximally.Itisshownthatthisproblemoffindingaredicaterenamingtoachieveminimal'non-Hornness'isNP-complete.

简介：Akineticequationofnon-isothermalcrystamzationwasderivedbyextendingAvrami’sequationtothenon-isothermalsituation.Morecrystallizationinformationcanbeobtainedfromthiskineticequation.Thecurvesofnon-isothermalandisothermalcrystallizationswereanalysedandcomparedforpoly(ethyleneterephthalate)(PET),andtheresultswerediscussed.

简介：Non-invasiveventilation(NIV)istheprovisionofventilatorysupportwithoutinstrumentationoftheairway.Itcanbeachievedusinganegative-pressuremachine(e.g.‘ironlung')or,morecommonly,withpositivepressureadministeredthroughawell-fittingmask.Thiscontributionconsiderspositivepressureventilationonly;negativepressureisnowseldomused.

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简介：为光滑的功能的一个家庭，作者显示出那，在某些通用条件下面，所有extremal(最小、最大)点是非退化的。

简介：在这篇论文，非各向同性的Jacobi假光谱方法被建议，它的应用斧子考虑了。一些结果在上；多维的Jacobi高斯类型插值和相关Bernstein杰克森类型不平等斧子建立了，它起一个重要作用在假光谱方法。假光谱方法被用于一二--维的单个问题中间axisymmetric上的一个问题领域。建议计划的集中被建立。数字结果表明建议方法的效率。

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