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简介：Injurytoaxonsclosetotheneuronalbodiesinthemammaliancentralnervoussystemcausesalargeproportionofparentingneuronstodegenerate.Itisknownthatopticnervetransectionclosetotheeyeinrodentsleadstoalossofabouthalfofretinalganglioncellsin1weekandabout90%in2weeks.Usinglowlevellasertreatmentinthepresentstudy,wedemonstratedthattreatmentwithhelium-neon(660nm)laserwith15mWpowercoulddelayretinalganglioncelldeathafteropticnerveaxotomyinadulthamsters.Theeffectwasmostapparentinthefirstweekwithashortperiodoftreatmenttime(5minutes)inwhich65–66%ofretinalganglioncellssurvivedtheopticnerveaxotomywhereas45–47%ofretinalganglioncellsdidsoinopticnerveaxotomycontrols.Wealsofoundthatsingledoseandearlycommencementoflaserirradiationwereimportantinprotectingretinalganglioncellsfollowingopticnerveaxotomy.Thesefindingsthusconvincinglyshowthatappropriatelasertreatmentmaybeneuroprotectivetoretinalganglioncells.更多还原

简介：Nestin+neuronshavebeenshowntoexpresscholineacetyltransferase(ChAT)inthemedialseptum-diagonalbandofBrocainadultrats.Thisstudyexploredtheprojectionofnestin+neuronstotheolfactorybulbandthetimecourseofnestin+neuronsinthemedialseptum-diagonalbandofBrocainadultratsduringinjuryrecoveryafterolfactorynervetransection.Thisstudyobservedthatallnestin+neuronsweredouble-labeledwithChATinthemedialseptum-diagonalbandofBroca.Approximately53.6%ofnestin+neuronswereprojectedtotheolfactorybulbandco-labeledwithfastblue.Alargenumberofnestin+neuronswerenotpresentineachregionofthemedialseptum-diagonalbandofBroca.Nestin+neuronsinthemedialseptumandverticallimbofthediagonalbandofBrocashowedobviouscompensatoryfunction.Thenumberofnestin+neuronsdecreasedtoaminimumlaterthannestin–/ChAT+neuronsinthemedialseptum-diagonalbandofBroca.Theresultssuggestthatnestin+cholinergicneuronsmayhaveacloserconnectiontoolfactorybulbneurons.Nestin+cholinergicneuronsmayhaveastrongertolerancetoinjurythanNestin–/ChAT+neurons.Thedifferencebetweennestin+andnestin–/ChAT+neuronsduringtherecoveryprocessrequiresfurtherinvestigations.

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