简介:Besidesthesameperformanceastheearthquakeobservationsystempossessusedonthefixedearthquakestation,suchaswidedynamicrange,highresolution,followingspecialfeaturesarenecessaryfortheearthquakedataacquisitionsystem(EDAS)appliedformobileobservinginordertosuitforrunninginthefield:a)Reliability.TheEDASmustworkstablylongtimewithoutbeingcared.b)Adaptabilitytothefieldenvironments.Earthquakeobservinginthefieldoftenencountersawfulenvironments,suchasdampness,dust,andabnormalclimate,sohowtomaketheinstrumentrunwellinthefieldcircumstancemustbeconsidered.c)Abilityofanti-vibration.Theinstrumentforoutdoorapplicationmustkeepfreefrombeingdestroyedduringbeingtransportedlongdistancetothedestination.d)Storagecapacity.Becauseseismologicaldataislarge,howtostoreandcollectthelargeamountdataconvenientlyfromthefieldisalwaysadifficultpointinthemobileobservingsystemdesign.e)Automation.Timingandpositioningautomaticallyisnecessaryinthefield.f)Powerconsumption.Toreducethepowercon-sumptionaslowaspossibleisveryimportanttothemobileinstrumentwhicharepoweredwithbattery.g)Abilityoftestingitself.Testingitselfautomaticallymakeitconvenientinthefieldwork.h)Portability.Theinstrumentmustbeportableandsimplyoperated.
简介:目的研究瘦素对2型糖尿病小鼠糖脂代谢及肝功能的改善作用,并从氧化应激、内质网应激和胰岛素抵抗等方面探讨其可能机制。方法选用瘦素缺陷的ob/ob小鼠作为2型糖尿病模型,根据是否给予瘦素处理分为两组(1mg/(kg·d),腹腔内注射);选用野生型C57BL/6J小鼠为正常对照。测定血清甘油三酯(triglycer-ide,TG)和总胆固醇(totalcholesterol,TC)反映脂质代谢状况,血清谷丙转氨酶(alaninetransaminase,ALT)和谷草转氨酶(aspartateaminotransferase,AST)反映肝功能;酶联免疫吸附实验测定胰岛素水平;Westernblot检测氧化应激指标还原烟酰胺腺嘌呤二核苷酸磷酸氧化酶4(nicotinamideadeninedinucleotidephosphatereducedoxidase4,NOX4)和过氧化氢酶(catalase,CAT)、内质网应激标志葡萄糖调节蛋白78(glucose-regulatedprotein78,GRP78)水平,胰岛素调控糖脂代谢通路蛋白激酶B(proteinkinaseB,AKT)的激活。结果与野生型小鼠比较,ob/ob小鼠血糖、TG和TC、ALT和AST活力以及胰岛素水平皆升高(均有P〈0.05);与ob/ob小鼠比较,经瘦素处理的ob/ob小鼠血糖、TG和TC、ALT和AST活力以及胰岛素水平皆下降(均有P〈0.05)。与野生型小鼠比较,ob/ob小鼠肝脏NOX4和GRP78水平增高(均有P〈0.05),CAT和p-AKT水平降低(均有P〈0.05);与未经瘦素处理的ob/ob小鼠相比,经瘦素处理的ob/ob小鼠肝脏中NOX4、GRP78降低(均有P〈0.05),CAT和p-AKT升高(均有P〈0.05)。结论瘦素可改善2型糖尿病小鼠糖脂代谢和肝功能,作用机制可能与其减轻肝脏氧化应激和内质网应激以及恢复对胰岛素的敏感性有关。
简介:C2C的模式在中国完成了培养用户网络购物习惯的使命,而最终要盈利却不得不绕道B2C。4月17日,易趣网副总裁常琳的晚餐时间是和易趣新平台上的个人大卖家们一起度过的。席间,那些自eBay易趣时代就栖身此处的大卖家们不断地向常琳提出各种吸引卖家进驻的建议。