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简介：ＪｉｎＳｈａｎｇｙｉａｎｄＨｉｓＰａｉｎｔｉｎｇｓＢｙｓｔａｆｆｒｅｐｏｒｔｅｒＤＩＡＮＣｈｉｎｅｓｅａｒｔｉｓｔｓｈａｖｅｎｏｔｈａｔｔｈｅｅａｓｉｅｓｔｔｉｍｅａｄａｐｔｉｎｇｔｈｅｍｓｅｌｖｅｓｔｏＷｅｓｔｅｒｎａａｒｔｆｏｒｍｓ，ｄｕｅｅｉｔ...

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简介：

简介：誓死捍卫奥运圣火的“轮椅上的微笑天使”、“最美丽的火炬乎”金晶，以无所畏惧的勇敢表现，让全世界认识了她。现在让我们走近这个乐观、坚强、自信的女孩。

简介：Forthehealthymanagementofplantation,ahealthassessmentindicatorsystemwasdesignedatforeststandscaleforthelarchplantationinJin'oulingForestFarm,WangqingForestryBureau,JilinProvince.Thesystemconsistedof3categories—foreststructure,externalinterferencesandmanagementobjectives,with15indicators.Theresultsshowedthat:1)theassessmentindicatorsystemwasscientificandrationalfordifferentagegroupsoflarchplantations;2)boththehalf-maturelarchplantationand...

简介：摘要水墨画，又称国画，是中国特有的一种传统绘画艺术形式。萧山区瓜沥镇党山幼儿园于2013年成为萧山区“自主性美术活动”试点园，2015年“水墨馆”正式成立，旨在通过水墨体验活动，让幼儿喜欢水墨、了解水墨，并从中习得一定的笔墨知识。我们从三方面着手增添水墨活动趣味性环境入手、趣绘畅玩、赏评推进。从环境创设、材料提供、趣味性的活动内容和形式，以及有效的赏评活动等方面入手，激发幼儿兴趣，循序渐进地让幼儿感知、了解水墨的特性，丰富审美情趣，体验自由表达和创造的快乐。

简介：ＡｎａｌｙｓｉｓｏｆｆｕｔｕｒｅｓｅｉｓｍｉｃｉｔｙｏｆＪｉｎｇ－Ｊｉｎ－Ｔａｎｇｒｅｇｉｏｎａｎｄｓｅｖｅｎｍａｊｏｒｓｅｉｓｍｉｃｚｏｎｅｓ　ｗｉｔｈｔｈｅｅｘｔｒｅｍｅ－ｖａｌｕｅｔｈｅｏｒｙＲａｎＺＨＯＵ（周冉）ａｎｄＢａｎｇ－ＨｕｔＬＩＮ（...

简介：Resistancetocisplatin(DDP)-basedchemotherapyisamajorcauseoftreatmentfailureinhumangastriccancer(GC).Itisnecessarytoidentifythedrugstore-sensitizeGCcellstoDDP.Inourpreviousresearch,ZuoJinWanFormula(ZJW)hasbeenprovedcouldincreasethemitochondrialapoptosisviacofilin-1inaimmortalizedcellline,SGC-7901/DDP.Duetotheimmortalizedcellsmaystilldifficulthighlyrecapitulatetheimportantmoleculareventsinvivo,primaryGCcellsmodelderivedfromclinicalpatientwasconstructedinthepresentstudytofurtherevaluatetheeffectofZJWandtheunderlyingmolecularmechanism.ImmunofluorescentstainingwasusedtoindentifyprimaryculturedhumanGCcells.Westernblottingwascarriedouttodetecttheproteinexpression.CellCountingKit-8(CCK-8)wasusedtoevaluatecellproliferation.Flowcytometryanalysiswasperformedtoassesscellapoptosis.ZJWinhibitedproliferationandinducedapoptosisinprimaryDDP-resistantGCcells.Notably,theapoptosisinGCcellswasmediatedbyinducingcofilin-1mitochondrialtranslocation,down-regulatingBcl-2andup-regulatingBaxexpression.Surprisingly,thelevelofp-AKTproteinwashigherinDDP-resistantGCcellsthanthatoftheDDP-sensitiveGCcells,andtheactivationofAKTcouldattenuateZJW-inducedsensitivitytoDDP.ThesedatarevealedthatZJWcanincreasethechemosensitivityinDDP-resistantprimaryGCcellsbyinducingmitochondrialapoptosisandAKTinactivation.ThecombiningchemotherapywithZJWmaybeaneffectivetherapeuticstrategyforGCchemoresistancepatients.