简介：AreviewarticlebyHaoetal.(JAmCollCardiol2017;69(24):2952–66)hashadhugerepercussionsamongthosefamiliarwithtraditionalChinesemedicine(TCM)intheinternationalacademiccommunity.ItevaluatedtheefficacyandsafetyofTCMforcardiovasculardiseaseandthepharmacologicaleffectofactiveTCMingredientsonthecardiovascularsystemandpotentialmechanisms.Wehaveseveralcomments:Firstly,wegiveabriefsummaryaddressingnonpharmacotherapyinTCM,includingacupuncture,moxibustion,Qigong,andTaiChi.Secondly,wehaveaddedtraditionalantiarrhythmicdrug–relatedrandomizedcontrolledtrialstomakethecoveragemorecomprehensive.Lastly,wesupporttheconceptthatresearchinto,developmentof,andapplicationofactiveingredientsispartofmodernTCM.

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简介：Inthispaper,theefficiencyof6kindsoffiltermaterials(polyesterfiber,cottonwool,celluloseacetate,polyvinylalcoholfiber,vinylonfiberandco-wovenfiber)spe-cificforleukocytedepletionfromredbloodcellswasevaluatedrespectively.Thedatademonstratedthatco-wovenfilterwasmosteffectiveintheremovalofleukocyte,fol-lowedbyvinylonfiber.Theleukocytedepletioncapacityandproprietyofco-wovenfibersdesignedforremovingleukocytefromwholebloodorredbloodcellconcen-

简介：FUNCTIONSOFCELLSSCAFFOLDINTHETISSUEENGINEERINGCell,cellsscaffoldandtheconstructionoftissueandorganarethreemainfactorsfortheTissueEngineering.Amainfunctionofcellsscaffoldintissueengineeringistoprovideanenvironmentforcellspropagation.

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简介：Skiniscomposedofbothadermallayer-consistingprimarilyoffibroblasts,andmatrixmacromolecules(ECM)-andanepidermallayer-composingofepidermalcellscontainingkeratinfilamentsundergoingprogressivedifferentiationfromabasalproliferatinglayertoasurfaceconsistingofterminallydifferentiated,epidermalcellsthatprotecttheskinfromtheenvironment.

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简介：AbstractBackground:The fetal growth charts in widest use in China were published by Hadlock >35 years ago and were established on data from several hundred of American pregnant women. After that, >100 fetal growth charts were published around the world. We attempted to assess the impact of applying the long-standing Hadlock charts and other charts in a Chinese population and to compare their ability to predict newborn small for gestational age (SGA).Methods:For this retrospective observational study, we reviewed all pregnant women (n = 106,455) who booked prenatal care with ultrasound measurements for fetal biometry at the Shenzhen Maternity and Child Healthcare Hospital between 2012 and 2019. A fractional polynomial regression model was applied to generate Shenzhen fetal growth chart ranges for head circumference (HC), biparietal diameter (BPD), abdominal circumference (AC), and femur length (FL). The differences between Shenzhen charts and published charts were quantified by calculating the Z-score. The impact of applying these published charts was quantified by calculating the proportions of fetuses with biometric measurements below the 3rd centile of these charts. The sensitivity and area under the receiver operating characteristic curves of published charts to predict neonatal SGA (birthweight <10th centile) were assessed.Results:Following selection, 169,980 scans of fetal biometry contributed by 41,032 pregnancies with reliable gestational age were analyzed. When using Hadlock references (<3rd centile), the proportions of small heads and short femurs were as high as 8.9% and 6.6% in late gestation, respectively. The INTERGROWTH-21st standards matched those of our observed curves better than other charts, in particular for fat-free biometry (HC and FL). When using AC<10th centile, all of these references were poor at predicting neonatal SGA.Conclusions:Applying long-standing Hadlock references could misclassify a large proportion of fetuses as SGA. INTERGROWTH-21st standard appears to be a safe option in China. For fat-based biometry, AC, a reference based on the Chinese population is needed. In addition, when applying published charts, particular care should be taken due to the discrepancy of measurement methods.

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简介：Manypatientswithsensorineuralhearinglosshaveaprecipitoushigh-frequencylosswithrelativelygoodthresholdsinthelowfrequencies.Thispresentpaperbrieflyintroducesandcomparesthebasicprinciplesoffourtypesoffrequencyloweringalgorithmswithemphasisonnonlinearfrequencycompression(NLFC).AreviewoftheeffectsoftheNLFCalgorithmonspeechandmusicperceptionandsoundqualityappraisalisthenprovided.Forvowelperception,itseemsthatthebenefitsprovidedbyNLFCarelimited,whichareprobablyrelatedtotheparametersettingsofthecompression.Forconsonantperception,severalstudieshaveshownthatNLFCprovidesimprovedperceptionofhighfrequencyconsonantssuchas/s/and/z/.However,afewotherstudieshavedemonstratednegativeresultsinconsonantperception.Intermsofsentencerecognition,persistentuseofNLFCmightprovideimprovedperformance.Comparedtotheconventionalprocessing,NLFCdoesnotalterthespeechsoundqualityappraisalandmusicperceptionaslongasthecompressionsettingisnottooaggressive.Inthesubsequentsection,therelevantfactorswithregardtoNLFCsettings,time-courseofacclimatization,listenercharacteristics,andperceptualtasksarediscussed.AlthoughtheliteratureshowsmixedresultsontheperceptualefficacyofNLFC,thistechniqueimprovedcertainaspectsofspeechunderstandingincertainhearing-impairedlisteners.LittleresearchisavailableonspeechperceptionoutcomesinlanguagesotherthanEnglish.MoreclinicaldataareneededtoverifytheperceptualefficacyofNLFCinpatientswithprecipitoushigh-frequencyhearingloss.Suchknowledgewillhelpguideclinicalrehabilitationofthosepatients.

简介：Inanefforttodevelopamethodforcartilagetissueengineering,researcherssuccessfullyusedcartilagecellsfromcowkneejoints.Bycreatingasuccessfulmethodwithconditionsconducivetogrowinghealthycartilagetissue,thefindingscouldhelpleadtoanewtreatmentcureforosteoarthritisusingstemcell-basedtissueengineering.Articularcartilageistissuethatisfoundonallthejointsurfacesinthebody.Sincethetissueis

简介：AIMTo估计角膜的矩阵作为脚手架过去常重建的非细胞组成的驼鸟张力亢进的盐溶液与一个消化方法相结合的损坏cornea.METHODSA习惯于decellularize驼鸟角膜。非细胞组成的角膜的矩阵的微观结构被传播电子显微镜学(TEM)和hematoxylin和曙红观察(H&；E)染色。机械性质被一个电流计和一台紧张机器检测。非细胞组成的角膜的矩阵也被移植进一个兔子角膜和cytokeratin3被用来检查有免疫力的phenotype.RESULTSThe微观结构和驼鸟角膜的机械性质很好在decellularization过程以后被保存。在vitro，甲基thiazolyltetrazolium结果表明非细胞组成的驼鸟角膜(AOC)的摘录没在增长上有禁止的效果角膜上皮或endothelial房间或在keratocytes上。兔子当角膜的混浊和接枝溶解发生在非细胞组成的猪的角膜(APC)时，薄片状的keratoplasty证明移植AOC进主人角膜透明、完全合并移植。重建的角膜的显型类似于有3首先在表面的上皮的房间layer.CONCLUSIONWe使用了的cytokeratin的高表情的一个正常兔子角膜重建的脚手架损坏了角膜的AOC。与猪的角膜相比，驼鸟角膜的解剖结构人的角膜接近那些。根据原则，那结构决定功能，薄片状的keratoplasty也证实了的异种皮移植AOC移植与APC接枝的相比产生了优异结果。

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简介：During2004,atotalof124batchesofHIVantibodyELISAsfromdomesticandoverseasmanufacturers,comprisingapproximately60milliontests,weretestedforqualityandreleasedforscreeningbloodinChina.Theinter-andintra-batchvariation,specificity,andsensitivitywereevaluatedusingalaboratorypanelandclinicalsamples.Theinter-batchvariationwaslessthan15%andonly2of12assayshadintra-batchvariationoflessthan20%for4dilutionsofacontrolspecimen.257samplesconfirmedpositiveforHIVantibodyand4826negativesamplesfromdifferentregionsinChinawereusedtoevaluatethesensitivityandspecificityoftheassays.Theresultsshowedthatthesensitivityisintherangefrom93.7%to100%forassayssampleddirectlyfromthemanufacturers,and91.4%-99.6%forthoseretrievedfromtheconsumers;thespecificitywasintherangefrom97.88%to99.97%.ThetestingenvironmentmayvaryindifferentregionsofChina.Therefore,manufacturersshouldproviderobustassaystosatisfytherequirementsofthesediverseenvironments,andespeciallyreducetheintra-assayvariationandimprovethestabilityofthekits.

简介：背景：训练的整个身体颤动(WBV)出现到豆子为在更老的个人训练的常规抵抗的有效选择。到目前为止，没有数据在心和肺的健康上关于振动效果存在。目的：这随机的ised控制了估计的试用在超过60岁的社区住所成年人在心和肺的健康和肌肉力量上训练的1年的WBV的效果。方法：220个成年人的一个总数(意味着年龄67.1年)随机被分到一个WBV组，健康组或控制组。在一个颤动平台上行使的TheWBV组，和健康组表演了心血管，抵抗，平衡和拉长的锻练。控制组没参予任何训练。心率在一个单个WBV会议期间被测量。山峰氧举起(VO2peak)和time-to-peak锻练(TPE)在进步自行车ergometry期间被测量。肌肉力量被一个测力计估计。结果：心率在WBV训练期间显著地增加了。在1年以后，VO2peak,TPE和肌肉力量在WBV和健康组显著地增加了。两个都训练的组在VO2peak和肌肉力量同样改善了。健康组比WBV组在TPE更显著地改善了。结论：WBV在社区住所训练老看起来有效改进心和肺的健康和肌肉力量。

简介：AbstractCyclone Idai, which hit Mozambique in March 2019, was one of the worst climate-related natural disasters on record in the Southern Hemisphere causing massive destruction of housing and disruption to vital infrastructure including the electrical grid, communications and water supply. Almost two million people were affected with over 600 deaths, hundreds of thousands of people displaced accompanied by rapid spread of cholera. We describe emergency measures taken by the Government of Mozambique, in collaboration with multilateral partners, to establish a real-time disease surveillance system, implement interventions recommended by a Water, Sanitation and Hygiene (WASH) taskforce and rapidly scale up a massive community vaccination program to control a cholera epidemic.

简介：T助手(Th)系被在极化期间与anti-CD3/CD28抗体激活CD4房间在vitro产生了。然而，生理地，Th系的产生被介绍抗原的房间(APC)被有特定的抗原的激活介绍。这里，我们使用了T房间受体(TCR)当在二个激活模式中的任何一个一个产生了时，比较Th1，Th9和Th17系的显型的转基因的老鼠。对母鸡鸡蛋溶解酵素(司死亡及冥府的女神)特定的系Th房间，采纳地被变成转基因地在他们的透镜表示司死亡及冥府的女神的接受者老鼠。显著差别在Th1，Th9或Th17的系之间被发现，在他们的能力在二个模式中的任何一个一个产生了移居到并且在接受者怒气并且，重要地增殖在接受者老鼠眼睛导致发炎。实质的差别也在他们某些chemokines和chemokine受体的抄本表示侧面在系对之间被观察。然而，令人惊讶地，靠近的类似在三显型的系的抄本表示侧面之间被观察，由一样的模式激活。而且，二个激活模式产生的Th房间系在他们基因表示的模式更加不同，由microarray分析监视了，但是与一样的激活模式产生的另外的显型的系展出了公共。这研究因此证明激活与anti-CD3/CD28抗体产生的(i)Th系不同于antigen/APC产生的系；并且(ii)激活的模式决定主要抄本的表示侧面到大程度。

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