简介：Livercelltransplantationpresentsclinicalbenefitinpatientswithinbornerrorsofmetabolismasanalternative,oratleastasabridge,toorthotopiclivertransplantation.Thesuccessofsuchatherapeuticapproachremainslimitedbythequalityofthetransplantedcells.Cryopreservationremainsthebestoptionforlong-termstorageofhepatocytes,providingapermanentandsufficientcellsupply.However,isolatedadulthepatocytesarepoorlyresistanttosuchaprocess,withasignificantalterationboth...

简介：Objective:Theexpressionoftumorbiomarkersmaychangeafterchemotherapy.However,whethersecretedproteinacidicandrichincysteine(SPARC)expressionchangesafterchemotherapyingastriccancer(GC)isunclear.ThisstudyinvestigatedtheinfluenceofchemotherapyonSPARCexpressioninGC.Methods:ImmunohistochemistrywasusedtoanalyzeSPARCexpressionin132GCcases(including54caseswithpreoperativechemotherapyand78caseswithoutpreoperativechemotherapy).SPARCexpressionofpostoperativespecimenswithandwithoutpreoperativechemotherapywasassessedtoanalyzetheinfluenceofchemotherapyonSPARCexpression.Results:SPARCwashighlyexpressedinGCcomparedwiththedesmoplasticstromasurroundingtumorcellsandnoncanceroustissues.HighSPARCexpressionwascorrelatedwithinvasiondepth,lymphnode,andTNMstage.Afterchemotherapy,alowerproportionofhighSPARCexpressionwasobservedinpatientswithpreoperativechemotherapythaninthecontrols.For54patientswithpreoperativechemotherapy,grosstype,histology,depthofinvasion,lymphnode,TNMstage,andSPARCexpressionwererelatedtooverallsurvival.Furthermultivariateanalysisshowedthatlymphnode,histology,andSPARCexpressionafterchemotherapywereindependentprognosticfactors.Conclusion:SPARCexpressionmaychangeafterchemotherapyinGC.SPARCexpressionshouldbereassessedforpatientswithGCafterchemotherapy.

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简介：Objective:Toinvestigatetheroleandclinicalsignificanceofp16proteininCondylomaAcuminatum(CA)anditscancerization.Methods:Theexpressionofp16proteinwastestedin33CAsamplesand7cancerizedCAsamplesbyimmunohistochemicalassays.Results:Therewasabnormalexpressionofp16proteininCAandcancerizedCA,mainlymajorproteinexpression.Thep16proteinexpresseedindifferentlocationsindifferentcaseswasasfollows:Inbasallayercellsinnormalcuits;inspinouslayer,granularlayerandstratumcorneumlayercellsinCA;inkeratinpearlperipheralandspinouslayercellsincancerizedCA.Conclusion..Therewasmajorexpressionofp16proteininCAandcancerizedCA,andtheseproteinofthetwogroupsmightnotnaturallybethesame.Ourstudyindicatedthatinclinicalpractice,whenmajorp16proteinexpressioninCAoccurs,it'sriskofcancerizationshoudbesuspected.

简介：当前transrectal指导超声的前列腺活体检视(TRUS-Bx)是最普通的urological过程之一，在经历TRUS-Bx的病人之中在欧洲和统一States.1每年与超过100万表现了，约三分之一个将收到前列腺癌症(PCa)的诊断，当三分之二在起始的活体检视上收到否定结果时。否定活体检视病人在1年维持12%的重复活体检视的估计的风险并且38%在5years.2标准TRUS-Bx是可能的系统地错过重要肿瘤，特别地在gland.3的前面、顶端的部分，在下一十年的泌尿科医师的一个关键目的是增加过程的精确性并且避免不恰当的活体检视的使用。

简介：ＥＸＰＥＲＩＭＥＮＴＡＬＲＥＳＥＡＲＣＨＯＦＥＬＦＥＭＦＯＮＣＨＡＮＧＥＯＦＨＥＭＯＲＨＥＯＬＯＧＩＣＡＬＰＲＯＰＥＲＴＹＡＮＤＤＥＳＩＧＮＯＦＥＬＦＥＭＦＧＥＮＥＲＡＴＯＲＥＸＰＥＲＩＭＥＮＴＡＬＲＥＳＥＡＲＣＨＯＦＥＬＦＥＭＦＯＮＣＨＡＮＧＥＯＦ...

简介：BackgroundRecentstudieshaveshowedthatperivascularadiposetissue(PVAT)maysecretetheadventitial-derivedrelaxingfactor(ADRF)toaffectvascularfunction.However,thefunctionalchangeofADRFinhypertensivestatusisseldomstudied;andthemechanismsofADRFremainunclear.OurstudyexaminedtheADRFsecretedbyperivascularadiposetissueofcontrolratswithnormalbloodpressure(WistarKyotorats,WKY)anddiscussedthemechanismsofADRF;WeobservedthefunctionalchangeinADRFofperivascularadiposetissueinspontaneouslyhypertensiverats(SHRs).MethodThetwoadjacentthoracicaortaringsofSHRandWKYratsweredividedintonakedvesselsubgroupandPVATsubgroup.Thedifferencesofvascularcontractilitybetweenthetwosubgroupsinducedby10-6mmol/Lphenylephrinewerecompared.TheeffectofPVATculturemediumofWKYonthevasculartensionofFat(-)vesselswasobservedbyliquidtransfermeasure.ThemechanismofADRFwasdeterminedbytooldrugs.ResultsInWKYgroup,vascularcontractilityofFat(+)subgroupwaslowerthanthatoftheFat(-)subgroup(P<0.05);whileinSHRgroup,therewasnodifferencebetweenthetwosubgroups(P>0.05).TransferringtheincubationsolutionofWKYFat(+)subgrouptothematchedFat(-)subgroupinducedrapidvasodilation.WhenincubatingbloodvesselsincalciumfreePSSsolution,therewasnosignificantdifferenceofphenylephrine-inducedvasoconstrictionbetweenFat(-)andFat(+)subgroup.Bothglibenclamide,theblockerofATP-sensitivepotassium(KATP)channelandTetraethy-lammoniumchloride(TEA),theinhibitorofcalcium-dependentpotassium(KCa)channel,effectivelyinhibitedvasodilationfunctionofADRF.ConclusionsPerivascularadiposetissueinWKYreleasesADRFwhichcancausevasodilation,whilethisfunctionwasinhibitedinSHR.ADRFactsthroughtheactivationofKCaandKATPchannelsandcalciumionisinvolved.

简介：ＴＨＥＨＥＭＯＲＨＥＯＬＯＧＹＣＨＡＮＧＥＩＮＩＳＣＨＥＭＩＣＲＥＧＩＯＮＢＹＣＯＲＯＮＡＲＹＳＴＥＮＯＳＩＳＡＦＴＥＲＬＡＳＥＲＩＲＲＡＤＩＡＴＩＯＮＯＮＢＬＯＯＤＴＨＥＨＥＭＯＲＨＥＯＬＯＧＹＣＨＡＮＧＥＩＮＩＳＣＨＥＭＩＣＲＥＧＩＯＮＢＹＣＯＲ...

简介：DearSir,IamDr.Yin-HungChangfromtheDepartmentofOtolaryngology,TaipeiTzuChiHospital,theBuddhistTzuChiMedicalFoundation.Iwouldliketopresentacaseofinvertedpapillomawithcarcinomachangeoflacrimaldrainageapparatusandnasalcavitythathadbeensuccessfullytreatedbyendoscopicsurgery.Lacrimaldrainageapparatustumorsarerarebutimportant

简介：AIMTo评估变化在phacoemulsification(PC)和femtosecond激光(FSL)期间帮助了的血压(BP)奔流surgery.METHODSA回顾的图表评论为从2013年7月收到了传统的phacoemulsification外科(PC组)和帮助FSL的奔流外科(FS组)到2014年12月的所有病人被执行。完全，从收到过程的二种类型的133个病人的206只眼睛被包括。耐心的特征(年龄，性，和高血压历史)，外科手术前、手术后的位／秒是收缩的collected.RESULTSThe支持operative，心脏舒张的位／秒(公里Hg)是124.89摥琠?桴?楳楬潣敮瀠畬？

简介：光谱表面EMG信号的精力分发经常被使用，但是困难地并且有效地控制人工的手足，因为光谱在手足行动的进程的精力分发变化。在这份报纸，表面EMG信号模式的一般特征第一被描绘由光谱精力变化。当他们的前臂肌肉是“疲劳”或“放松”时，13个健康题目被指示与他们的右前臂执行前臂旋后(FS)和前臂内转(FP)。所有表面EMG信号在他们的右前臂行动期间从他们的右前臂屈肌被记录。表面EMG信号的二个集合在准备舞台和代理舞台适当地从每个表面EMG信号被分割。相对小浪包精力(在准备舞台和代理舞台分别地由pnp和pna象征了，n表示第n个频率乐队)表面EMG，信号第一被计算然后，差别(Pn=Pna-Pnp)被获得。结果证明从一些频率乐队的Pn能有效地描绘表面EMG信号模式的一般特征。与在另外的频率乐队的Pn相比，P4，光谱从93.75～125Hz的精力变化，更适当地被认为是特征。

简介：AbstractRising emissions of greenhouse gases in the atmosphere have warmed the planet substantially and are also accompanied by poor air quality. The increased prevalence of allergic airway disease worldwide can be partially attributed to those global environmental changes. Climate change and air pollution pose adverse impacts on respiratory allergies, and that the mechanisms are complex and interactive. Adverse weather conditions, such as extreme temperatures, can act directly on the respiratory tract to induce allergic respiratory illnesses. Thunderstorms and floods can alter the production and distribution of aeroallergens while wildfires and dust storms increase air pollution, and therefore indirectly enhance health risks. Concentrations of particulate matter and ozone in the air have been projected to increase with climate warming and air stagnation, and the rising temperatures and CO2 increase pollen, molds, and spores, which escalate the risk of allergic respiratory diseases. The synergistic effects of extreme heat and aeroallergens intensify the toxic effect of air pollutants, which in turn augment the allergenicity of aeroallergens. With the Earth’s climate change, migration of humans and plants shift the living environments and allergens of susceptible people. Urban residents are exposed to multiple factors while children are sensitive to environmental exposure. Since climate change may pose many unexpected and persistent effects on allergic respiratory diseases, health professionals should advocate for effective mitigation and adaptation strategies to minimize its respiratory health effects.

简介：AbstractIt is unequivocal that human influence has warmed the planet, which is seriously affecting the planetary health including human health. Adapting climate change should not only be a slogan, but requires a united, holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately. Recognizing the urgent needs to tackle the risk connection between climate change and One Health, the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided.

简介：AIM:Tostudytheeffectsofglutamine(Gin)onthechangeofintestinalpermeabilityanditsrelationshiptosystemicinflammatoryresponseinearlyabdominalpostoperativepatients.METHODS:Aprospective,randomized,double-blindandcontrolledtrialwastaken.TwentypatientsundergoingabdominalsurgerywererandomizedintoGingroup(oraladministrationofglutamine,30g/d,for7d,n=10)andplacebogroup(oraladministrationofplacebo,30g/d,for7d,n=-10).Temperaturesandheartratesofallpatientsweredailyrecorded.Whitebloodcellcounts(WBC)andbiochemicalvariablesweremeasuredbeforeoperationand4and7dalterdrugadministration.Serumconcentrationsofglutamine,endotoxin,diamineoxidaseandmalondialdehydeandurinelactulose/mannito(L/M)ratioweremeasuredbeforeand7dalterdrugadministration.RESULTS:Thepatientsinthe2groupswerecomparablepriortodrugadministration.SerumGinconcentrationwassignificantlydecreasedintheplacebogroupandincreasedintheGingroup7dalterdrugadministration.UrineL/MratiowassignificantlyincreasedintheplacebogroupanddecreasedintheGingroup.Theserumconcentrationofendotoxin,diamineoxidaseandmalondialdehydewassignificantlydecreasedintheGingroupcomparedwiththoseintheplacebogroup.Temperatures,heartratesandWBCcountsweresignificantlylowerintheGingroupthanthoseintheplacebogroup.CONCLUSION:Gutisoneofthesourcesofsystemicinflammatoryresponseinabdominalpostoperativepatientsandglutaminecandecreaseintestinalpermeability,maintainintestinalbarrierandattenuatesystemicinflammatoryresponseinearlypostoperativepatients.

简介：Objective:Toexplorethecontentchangeofneurofilament(NF)proteinsubunitsintheexperimentalbraindiffuseaxonalinjury(DAI)bylateralheadrotation.Methods:Twenty-fourSpragueDawley(SD)ratswereequallydividedintothreeinjurygroups(2h,12h,and24hpostinjury)andonecontrolgroup.ThemodelsofDAIweremadeintheinjurygroupsbylateralheadrotation.westernblottingtechniquewasusedtomeasuretheconteneofNF68(akindofNFproteinsubunit)inthebrainstemtissuesamongalltheinjuredandcontrolrats.TheNF68immunohistochemicalstainingwasusedinanothersixSDratsinordertoobservethemorphologicalchangesinDAI.Results:TheNF68contentinthebrainstemtendedtodecreaseat2hpostinjury,decreasedsignificantlyat12handcontinueditsdecreaseat24h.NF56andNF52,asthebreakdownproductsofNF68,hadatendencytoincreaseat2-12haftertheinjury,andamountedtoasignificantlyhigherlevelat24h.Microscopically,therewerealotofswellingneuronalaxonsintheventralpartofthemedullaroblongateat2haftertheinjury.someaxonsweredisconnected,andaxonalretractionballsformedontheirproximalend.Conclusions:ThereisandoccurrenceofphosphorolysiswithinthebrainsteminDAIbylateralheadrotation.ThesereactionscausethebreakdownofNF68,whichresultsinthedecreaseofNF68incontent.ItsuggeststhatthebreakdownofneurofilamentproteinsubunitsisanimportantreasonforstructuraldestroyofneurofilamentsinDAI.

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简介：AbstractBackground:The peripheral perfusion index (PI), as a real-time bedside indicator of peripheral tissue perfusion, may be useful for determining mean arterial pressure (MAP) after early resuscitation of septic shock patients. The aim of this study was to explore the response of PI to norepinephrine (NE)-induced changes in MAP.Methods:Twenty septic shock patients with pulse-induced contour cardiac output catheter, who had usual MAP under NE infusion after early resuscitation, were enrolled in this prospective, open-label study. Three MAP levels (usual MAP -10 mmHg, usual MAP, and usual MAP +10 mmHg) were obtained by NE titration, and the corresponding global hemodynamic parameters and PI were recorded. The general linear model with repeated measures was used for analysis of variance of related parameters at three MAP levels.Results:With increasing NE infusion, significant changes were found in MAP (F = 502.46, P < 0.001) and central venous pressure (F = 27.45, P < 0.001) during NE titration. However, there was not a significant and consistent change in continuous cardiac output (CO) (F = 0.41, P = 0.720) and PI (F = 0.73, P = 0.482) at different MAP levels. Of the 20 patients enrolled, seven reached the maximum PI value at usual MAP -10 mmHg, three reached the maximum PI value at usual MAP, and ten reached the maximum PI value at usual MAP +10 mmHg. The change in PI was not significantly correlated with the change in CO (r = 0.260, P = 0.269) from usual MAP -10 mmHg to usual MAP. There was also no significant correlation between the change in PI and change in CO (r = 0.084, P = 0.726) from usual MAP to usual MAP +10 mmHg.Conclusions:Differing MAP levels by NE infusion induced diverse PI responses in septic shock patients, and these PI responses may be independent of the change in CO. PI may have potential applications for MAP optimization based on changes in peripheral tissue perfusion.

简介：瞄准：用液体血管注射剂硅酮与阴茎尺寸扩大报导我们的经验。方法：在2003年8月和2006年7月之间，324个人(意味着年龄35年，range19-65年)在阴茎柄的背面、侧面的方面上收到了在阴茎皮肤和阴茎海绵体之间的一系列液体硅酮皮下注射，在局部麻醉下面。数字相片拿的过程前并且过程以后(n=324)，并且阴茎轮廓大小(n=30)产出的客观结果。主观结果从病人和满足的搭挡证词被导出。后续平均20个月(范围1-36月)。结果：Threehundred和24个过程是主要扩大。大多数人(61%)结婚了，7%被他们的搭挡伴随，并且93%被割除。吝啬的测量阴茎圆周was9.5厘米(7.5-11.5厘米)预告的处理和12.1厘米(10.3-15.3厘米)处理以后(在直径的圆周和0.84厘米的27%的吝啬的增加)。病人和搭挡满足已经在开始的二治疗以后被表示。性欲活动能在8h以后被恢复。复杂并发症(温和檫伤)容易被解决。结论：阴茎尺寸扩大使用液体血管注射剂硅酮没有立即或短期的复杂并发症产出很令人满意的短期的结果。