简介：目的探讨心理护理在眼科护理中的应用.方法分别对3种眼病190位患者的心理变化进行总结和分析,并对患者实施了积极有效的心理护理及健康知识的教育.结果患者以一种良好的心态接受治疗和护理,并让患者对其所患疾病有了正确的认识,均情绪稳定.从而提高了治愈率,大大减少了并发症发生,患者对我们的服务质量较满意.结论对患者进行有效的心理护理可以建立良好的护患关系,让患者积极主动配合医护人员治疗,早日康复.

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简介：目的分析老年人视力损害的眼病病因及心理影响。方法收集眼科门诊60岁以上老人850例,分三组：60-69岁,70-79岁,≥80岁。检查视力、眼科仪器检查、评估心理状况,对数据进行统计分析。结果各视力级别的总比例：≥5.0（5.46%）,较好视力4.5-4.9（60.62%）,低视力4.0-4.4（24.34%）,盲〈4.0（9.58%）。在年龄组间随年龄增高,较好视力的比例下降（66.45%,57.11%,38.23%）,低视力（25.33%,35.54%,47.27%）和盲（5.12%,7.24%,14.50%）的比率升高,差异有统计学意义（P〈0.05）。随视力级别下降,心理状况水平优的人数比例而降低（90.13%,82.31%,34.24%,2.10%）,状况水平差的比例而升高（1.73%,5.46%,45.35%,85.44%）,差异有统计学意义（P〈0.05）。低视力和盲的主要眼病构成比：白内障52.33%,屈光不正20.11%,老年性黄斑变性14.32%,糖尿病视网膜病变7.02%,眼底静脉阻塞3.10%。结论老年人视力损害眼病前五位是白内障,屈光不正,老年性黄斑变性,糖尿病视网膜病变,眼底静脉阻塞。老年人低视力和盲的比例高,视力损害者不良心理状况比例高,视力损害对老年人心理状况的影响值得重视。

简介：目的：探讨低视力患者的心理健康状况及受到的社会支持。方法：从解放军总医院第一附属医院、同仁医院、中医眼科医院采用方便取样的方式抽取105例低视力患者进行调查。采用一般情况调查表、症状自评量表（SCL-90）、社会支持评定量表（SSRS）施测。结果：（1）低视力患者与社会常模进行比较,两者的SCL-90九个因子（除人际关系外）平均得分均存有显著性差异（P〈0.01或P〈0.05）。（2）不同年龄组被试在人际关系、焦虑、敌对、偏执、精神病五个因子上得分存在显著性差异（P〈0.05）。（3）SCL-90量表与社会支持量表的相关性研究表明社会支持总分与主观支持得分呈负相关,与客观支持与社会支持度上呈部分负相关。结论：低视力患者存在心理健康问题、主观上感受到的社会支持少,应注重低视力患者的心理护理。

简介：目的调查视网膜母细胞瘤（retinoblastoma,RB）患儿家长的心理健康状况。方法采用国际通用的焦虑自评量表和抑郁自评量表对121名患儿家长进行问卷调查,以国内常模作为对照。采用SAS8.0统计软件对数据进行t检验和方差分析。结果RB患儿家长的焦虑标准分（53.80±10.42）和抑郁标准分（58.90±10.89）均高于国内常模（P均〈0.0001）。双眼RB患儿家长的焦虑标准分（58.19±10.57）和抑郁标准分（62.46±11.84）明显高于单眼RB组（焦虑和抑郁值分别为51.73±9.77,57.22±10.09,P值分别为0.0083,0.0423）。患儿所处的治疗阶段不同,家长文化程度不同,家庭经济状况不同,家长的焦虑和抑郁程度也不同。结论RB患儿家长的焦虑、抑郁水平明显高于国内正常人群,提示对RB患儿家长进行心理疏导的必要性。

简介：在瞬息万变的信息化社会里,加强医学生创新能力的培养是适应医学发展的必要条件。本文结合眼科学的特点,初步探讨在眼科教学活动中医学生创新能力培养所存在的问题和解决方案,为提高医学生的创新能力,更好的服务临床提供帮助。

简介：AIM:Tostudythedistributionofocularhigher-orderaberrations(HOAs)andmesopicpupilsizeinindividualsscreenedforrefractivesurgery.·METHODS:OcularHOAsandmesopicpupilsizewerestudiedin2458eyesof1240patientswithmyopia,myopicastigmatismandcompoundmyopicastigmatismand215eyesof110patientswithhyperopia,hyperopicastigmatismandcompoundhyperopicastigmatismusingtheZywaveaberrometer(Busch&Lomb).Allpatientshadcorrectablerefractiveerrorswithoutahistoryofrefractivesurgeryorunderlyingdiseases.Root-mean-squarevaluesofHOAs,totalsphericalaberration,totalcomaandmesopicpupilsizewereanalyzed.OcularHOAsweremeasuredacrossa≥6.0mmpupil,andpupilsizemeasurementswereperformedunderthemesopiccondition.·RESULTS:ThemeanvaluesofHOAs,totalsphericalaberrationandtotalcomainthemyopicgroupwere0.369μm,±0.233,0.133±0.112μmand0.330±0.188μm,respectively.InthehyperopicgroupthemeanvaluesofHOAs,totalsphericalaberrationandtotalcomawere0.418μm±0.214,0.202±0.209μmand0.343±0.201μm,respectively.HyperopesshowedgreatertotalHOAs(P<0.01)andtotalsphericalaberration(P<0.01)comparedtomyopes.Inage-matchedanalysis,onlytheamountoftotalsphericalaberrationwashigherinthehyperopicgroup(P=0.05).Mesopicpupilsizeinthemyopicgroupwaslarger(P≤0.05).·CONCLUSION:TheresultssuggestedthatsignificantlevelsofHOAswerefoundinbothgroupswhichareimportantforplanningrefractivesurgeriesonIranians.Thereweresignificantlyhigherlevelsoftotalsphericalaberrationinhyperopescomparedtomyopes.Mesopicpupilsizewaslargerinmyopicgroup.

简介：为贯彻落实《中共中央国务院关于加强青少年体育增强青少年体质的意见》（中发[2007]7号）精神，加强保护学生视力的工作，特制定本工作方案。

简介：AIM:Toexploretheeffectofsaturatedhydrogensalineonbluelight-inducedretinaldamageinrats.·METHODS:Theretinaldamageofratswasinducedbybluelightexposurefor6hoursandexamined8hours,16hoursand24hoursaftertheexposure.OnehundredfemaleSprague-Dawleyratswererandomlydividedintofourgroups.Group1included30ratsreceivedlightexposurewithoutanyothertreatment.Group2included30ratsreceivedlightexposurewithintraperitonealinjectionofnormalsaline.Group3included30ratsreceivedlightexposurewithintraperitonealinjectionofsaturatedhydrogensaline.AndGroup4includedtheother10ratswhichdidnotreceiveanytreatment.Theamountofintraperitonealinjectionofsaturatedhydrogensalineandnormalsalinewascalculatedintheratioof1ml/100gofratweight.SpecimenswerecollectedandprocessedbyH-Estaining,ultrastructureobservation,biochemicalmeasurement.Morphologicalchangeswereobservedbylightmicroscopeandtransmissionelectronmicroscope(TEM)andtheretinalouternuclearlayer(ONL)thicknesswasmeasuredbyIPP6.0,whilethemalondialdehyde(MDA)wasmeasuredbycolorimetricdeterminationat532nm.·RESULTS:AlthoughthestructureofretinainGroup1andGroup2wasinjuredheavily,theinjuryinGroup3wasmild.ThedifferencesbetweenGroup1andGroup2werenotsignificant.ComparedwiththeratsinGroup1andGroup2,theonesinGroup3hadmoreclearlydemarcatedretinastructureandmoreorderedcellsbylightmicroscopeandTEMobservation.TheONLthicknesses(400times)offourgroupsateachtimepointexceptbetweenGroup1andGroup2weresignificantlydifferent(P<0.05).ThethicknessesoftheONLinGroup1atthreetimepointswere30.41±4.04μm,26.11±2.82μmand20.63±1.06μm,inGroup2were31.62±4.54μm,25.08±3.63μmand19.07±3.86μm,inGroup3were29.75±3.62μm,28.83±1.97μmand27.61±1.83μm.InGroup4themeanofthethicknesswas37.35±1.37μm.Astimewentby,thedamageg

简介：AIM:Anaerobicbacteriacancauseocularinfections.WetestedtheOxyPlateTMAnaerobicSystem(OXY)toisolatepertinentanaerobicbacteriathatcancauseoculardisease.METHODS:OXY,whichdoesnotrequiredirectanaerobicconditions(i.e.bags,jars),wascomparedtoconventionalisolationofincubatingculturemediainanaerobicbags.Standardcoloniescountswereperformedonanaerobicocularbacterialisolatesunderaerobicandanaerobicconditions(anaerobicbags)usingagarmedia:1)OXY(aerobiconly),2)5%sheepblood(SB),3)Chocolate,and4)Schaedler.Thebacteriatestedwerede-identifiedocularisolatesculturedfromendophthalmitisanddacryocystitisthatinclude10Propionibacteriumacnesand3Actinomycesspecies.Thecolonycountsforeachbacteriaisolate,oneachculturingcondition,wererankedfromlargesttosmallest,andnon-parametricallycomparedtodeterminethebestculturingcondition.RESULTS:Allanaerobicconditionswerepositiveforalloftheanaerobicisolates.SBandSchaedler’sagarunderaerobicconditionsdidnotsupportthegrowthofanaerobicbacteria.SparsegrowthwasnotedonchocolateagarwithPropionibacteriumacnes.Asananaerobicsystem,SBinananaerobicbagisolatedhighercolonycountsthanOXY(P=0.0028)andchocolateagar(P=0.0028).CONCLUSION:AlthoughOXYdidnottesttobemoreefficientthanotheranaerobicsystems,itappearstobeareasonablealternativeforisolatinganaerobicbacteriafromocularsites.Theuseofanagarmediuminaspeciallydesignedplate,withouttherequirementofananaerobicbag,renderedOXYasanadvantageoverotheranaerobicsystems.

简介：AIM:TodiscusstheimpactofLyciumBarbarumPolysaccharide(LBP)andDanshensupurifiedfromTraditionalChineseMedicine(TCM)onvascularendothelialgrowthfactor(VEGF)ofrabbitswithretinalneovascularization.METHODS:Fortyrabbitsweredividedintonormalcontrolgroup,modelcontrolgroup,LBPgroupandDanshensugroup.Animalsinthenormalcontrolgroupwerefedinthenormaloxygenenvironment.Animalsintheotherthreegroupswereputintotheenvironmentwith70%oxygenfor5daysinordertobuildthemodelofoxygen-inducedvascularproliferationretinopathy.AndthendifferentTCMextractwasinjectedintotheabdominalcavitiesoftheseannimals.After7days,theVEGFcontentofintheserumofrabbitwasmeasuredbydoubleantibodysandwichmethod.RESULTS:DataanalysisindicatedthatVEGFcontentwasasfollows:Danshensugroupwaslowerthanmodelcontrolgroup(12.92±3.84ng/Lvs19.32±4.15ng/L,P<0.05);LBPgroupandnormalcontrolgroupwerelowerthanmodelcontrolgroup(12.92±3.84ng/L,9.26±1.61ng/Lvs19.32±4.15ng/L,P<0.01);totalbloodviscosity,plasmaviscosity,cholesterolcontent,fibrinogencontentandtriacylglycerolcontentafterperitonealinjectionofLBPandDanshensuwereobviouslylowerthanbeforeinjection.CONCLUSION:TCMextract-LBPandDanshensucanprominentlyreducethecontentofVEGFintheprocessofvascularproliferativeretinopathyofrabbit;canpreventtheoccurrenceofretinalmicrovasculardiseasebyimprovingpartialoxygen-deficientenvironmentoraffectingallkindsofnewgrowthfactor.

简介：AIM:TopresenttheresultsofimplantationofIakymenkokeratoprosthesisinfivepatientswithvascularizedcornealleukomacausedbysevereocularinjury.·METHODS:Iakymenkokeratoprosthesiswasimplantedinto5eyesof5patients:4patientsweresufferedfromchemicalburnsand1patientfromexplosiveinjury.Thepreoperativevisualacuityrangedfromlightperceptiontohandmotion.Theimplantationsurgerywascomposedoftwo-stageprocedures.Thefollow-upperiodwasfrom9monthsto11years.Theoutcomemeasureswerevisualacuity,retention,andcomplicationsofthekeratoprosthesis.·RESULTS:Visionimprovementswereachievedinmostpatients.Allkeratoprosthesiswereretainedwithinthefollow-upperiod.Cornealmeltingoccurredinonepatientandfibrousclosureinanotherpatient,bothofwhichweresuccessfullytreated.Retinaldetachmentoccurredinonepatientaftersurgery.·CONCLUSION:Iakymenkokeratoprosthesisseemstobeapromisingalternativeforthepatientswithseverecornealinjury,butfurtherinvestigationisneededtoevaluatetheroleofIakymenkokeratoprosthesis.

简介：AIM:Toinvestigatethefrequencyofidiopathicphacodonesis(IP)insenilecataractsubjectsandtheshort-termclinicaloutcomesfollowingcataractsurgery.METHODS:Thisinstitutionalcase-controlstudyincluded1301consecutivelow-incomecataractsubjectsfromJunetoNovember2009.Anteriorsegmentwerecarefullyevaluatedwithdilatedpupilunderslit-lamp.IPwerescreenedandgradedbyacriteriasetbytheauthors.Riskfactors,surgicaloutcomes,andoperativecomplicationswereanalyzed.RESULTS:Atotalof42subjects(3.2%)withIPwerediagnosedandclassifiedasgrade1(36subjects),grade2(5subjects)andgrade3(1subject).HarderlensesandintumescentcataractswereobservedintheIPgroupthanthecontrolgroup(P<0.05).Logisticsregressiontestalsoindicatedthemainriskfactorwasthehardnessofthelens.Theincidenceofzonulardialysisduringsurgerywas23.8%(10eyes),whichwassignificantlyhigherthanthecontrols(0.7%,P<0.001).Visualoutcomesofthetwogroupswerenotstatisticallyorclinicallysignificant.CONCLUSION:HardnucleusandintumescentcataractarerelatedtoIPinsenilecataractsubjectsinQinghai,China.Withmorecarebeingtaken,grade1andsomeofthegrade2IPsubjectsachievedsimilarsurgicaloutcomesascomparedtocontrols.

简介：<正>DirSir,IamdoctorGuo-YuanYang,fromtheDepartmentofOphthalmologyofWestChinaHospitalofSichuanUniversityinChengdu,SichuanProvince,China.Iwritetopresentacasereportofposteriorlentiglobuswithcataract.

简介：AIM:Toevaluatechangesintheanteriorchamberdepth(ACD),crystallinelensthickness(LT)anditsrefractivepowerafterlaserinsitukeratomileusis(LASIK).·METHODS:Inallcases,thepreoperativeandpostoperativecentralACDwhichweremeasuredwithPentacam,Orbscan,IOL-MasterandA-scanultrasonography,centralcornealtruenetpowerwhichwasmeasuredwiththePentacam,OrbscanandIOL-Master,axiallength(AL)whichwasmeasuredwithIOL-MasterandLTwhichwasmeasuredwiththeA-scanultrasonographywerecomparedusingthepairedsamplettest.OcularrefractiveerrorsandlensrefractivepoweratcornealplanewerecalculatedandtheircorrelationswerealsoevaluatedbeforeandafterLASIK.RESULTS:At1weekafterLASIK,LTandcrystallinelensrefractivepoweratcornealplane(Dlens)whichwereassociatedwiththeIOL-MasterandPentacamincreasedsignificantly(P≤0.005),ACDdecreasedsignificantly(P≤0.001),butnosignificantincreasewasobservedintheDlenswhichwasassociatedwiththeOrbscan(P=0.261).SignificantcorrelationsbetweenthechangesintheocularrefractiveerrorsandDlenswhichwereassociatedwiththePentacamwereobservedat1weekand6monthsafterLASIK(P=0.028;P=0.001).CONCLUSION:LTincreasedsignificantlyafterLASIK,andthismightpartiallyleadtoACDdecrease,Dlensincreaseandasmallquantityofmyopicregression.

简介：AIM:ToexploretheinhibitoryeffectofasustainedcyclosporinA(CsA)deliverymicrosphere(CsA-MS)onposteriorcapsularopacification(PCO)inrabbiteyesaftercataractextraction.·METHODS:TwentyNewZealandwhiterabbitsacceptedcataractextractionplusintraocularlensimplantationandtheirlefteyeswereintraoperativelyinjectedCsA-MSpreparedusingpolymerpolylactioglycolicacid(PLGA)asacarrierandtheirrighteyeswereinjectedwithemptyMS.Thechangesincornea,anteriorchamberreaction,intraocularpressure,PCOandCsAconcentrationinaqueoushumorwereexaminedpostoperativelyandalltheeyeswereenucleated3monthsaftersurgeryforhistopathologicalandmorphologicalexaminationwithlightmicroscopyandelectronmicroscopy.·RESULTS:Conjunctivalhyperemia,cornealedema,intraocularpressureandanteriorchamberresponseofexperimentalandcontroleyesweresimilar,whilePCOinCsAMSinjectedeyeswasgreatlyimprovedcomparedwiththatincontroleyes.PosteriorcapsulesinCsA-MSinjectedeyesweresmoothandlensepithelialcells(LEC)didnotproliferatesignificantly(P>0.05),whileLECinposteriorcapsuleofcontroleyeshaddifferentdegreesofproliferationandcorticalregeneration.LECinCsA-MSinjectedeyeswerenotfunctionallyactiveandunderwentapoptosis,whereasLECincontroleyeswerefunctionallyactive(F-test,P=0.025).Inaddition,thecornealultrastructureshowednodifferencesbetweenCsA-MSandMSinjectedeyes.CONCLUSION:CsA-MShashighbioavailabilityinrabbiteyesandcouldinhibitpostoperativePCOoccurrenceanddevelopmentduringthestudyperiod,suggestingthatCsA-MSmaybeapromising,effectiveandsafeadministrationroutetopreventPCOinclinic.

简介：AIM:Toinvestigatetheefficacyofnon-buckledvitrectomywithclassicalendotamponadeagentsinthetreatmentofprimaryretinaldetachment(RD)complicatedbyinferiorbreaksandproliferativevitreoretinophathy(PVR).METHODS:Aretrospective,consecutiveandcaseseriesstudyof40patientswithinferiorbreakRDandPVR≥C1wasconducted.Allpatientsunderwentastandard3-port20-gaugeparsplanavitrectomy(PPV)withgasorsiliconeoiltamponadewithoutsupplementaryscleralbuckling.Thevitreousandallproliferativemembranewerecompletelyremoved,andretinectomywasperformedwhennecessary.Themeanfollow-upwas12.5months.Theprimaryandfinalanatomicsuccessrate,visualacuityandcomplicationswererecordedandanalyzed.RESULTS:Primaryanatomicsuccessratewasachievedin35of40eyes(87.5%)andthefinalanatomicsuccessratewas100%.ThemostcommoncauseofredetachmentwasrecurrentPVR.Thebest-correctedvisualacuity(BCVA)atfinalfollow-upwasimprovedin34eyes(85%),remainedstablein1eye(2.5%),andworsenedin5eyes(12.5%).Themeanvisualacuityatfinalfollow-upwasimprovedsignificantly(P=0.000).CONCLUSION:ThisretrospectivestudyprovidesevidencethatvitrectomywithoutscleralbucklingseemedtobeaneffectivetreatmentforinferiorbreakRDwithPVR.Withcompleteremovalofvitreousandproliferativemembranesandtimingofretinectomy,theinferiorbreakswhichcomplicatedwithPVRcouldbeclosedsuccessfullywithoutadditionalscleralbuckling.

简介：AIM:ToinvestigatetheeffectofY-27632onthesurvivalandneuriteoutgrowthoftheculturedretinalneurocytes.METHODS:Afterthepostnatalday2-3,Sprague-Dawleyretinalneurocyteswereculturedfor48hours,theculturemediawasreplacedwithserum-freemedia(controlgroup)andserum-freemediacontained30μmol/LY-27632(Y-27632group),andthecellswerecontinuallyculturedanother48hours.Theculturedretinalneurocyteswereidentifiedwithanti-neuronspecificenolase(NSE)immunocytochemistry.ThesurvivalstateofthosecellswasestimatedbyMTTassay,andtheneuriteoutgrowthofthosecellswasevaluatedbythecomputerizedimage-analysissystem.RESULTS:Comparedwiththecontrolgroup,theabsorbancevaluesofcellssurvivalinY-27632groupincreased12.90%and33.33%respectivelyafter72and96hoursculture.Y-27632hadnosignificanteffectonthediameterofculturedretinalneurocytes.Comparedwiththecontrolgroup,Y-27632inducedastableimprovementofneuriteoutgrowthofretinalneurocytesafter72and96hoursculture(P=0.001).CONCLUSION:Y-27632couldpromotethesurvivalandneuriteoutgrowthoftheearlypostnatalculturedretinalneurocytes.

简介：AIM:Toevaluatetheepidemiologic,anatomic,andclinicalfeaturesofopenglobeinjuriesinchildren.METHODS:Themedicalfilesofpatientsundertheageof16whohadbeenoperatedforanopenglobeinjuryatAkdenizUniversityHospital’sDepartmentofOphthalmologywereretrospectivelyevaluated.RESULTS:Atotalof90patientswereevaluatedinthisstudy.Amongthesepatients,26(28.9%)werefemaleand64(71.1%)weremale.Themeanageofthepatientswas7.7±4.2years.Themale/femaleratiowasobservedtoincreasewithincreasingage(P=0.006,P=7.48).Injuriesweremostlikelytooccurinspringandautumn(P=0.028).Thetimeintervalbetweentheinjuryandthesurgicalrepairwas9.36±27.4h.Forty(44.4%)oftheinjuriesoccurredinthehome,27(30%)occurredintheyard,and21(23.3%)happenedwhileplayinginthestreet.Themostcommoncausesofinjuryweresharpmetalobjects(P<0.001).Injurytothecorneaoccurredin47(52.2%)ofthepatients(P<0.001).Themostcommoncomplicationtooccurwascataractformation.Additionaloperationswerenecessaryfor37(41.1%)ofthepatients.Thefinalvisualacuitywascorrelatedwithboththeinitialvisualacuityofthewoundedeyepriortosurgeryandthelengthofthewound(P<0.001,r=0.502andP<0.001,r=-0.442,respectively).CONCLUSION:Openglobeinjuriesthataresufferedinchildhoodgenerallyoccureitherathome,intheyard,oronthestreet,withsharpmetalobjectsbeingthemostcommoncauseofinjury.Theinitialvisualacuityandthelengthofthewoundarethemostimportantdeterminantsofthefinalvisualacuity.

简介：AIM:Tocharacterizetemporalpatternofresolutionandrecurrenceofnaivechoroidalneovascularization(CNV)secondarytowetage-relatedmaculardegeneration(AMD)treatedwithintravitrealbevacizumabonasneededregimen,andtoanalyzebaselineriskfactorsforCNVresolutionorrecurrence.METHODS:Ninety-oneeyesof80patientswithnewlydiagnosedwetAMDwereretrospectivelystudied.Alleyesweretreatedwitharoundofthreemonthlyintravitrealbevacizumabinjections,followedbyoneadditional’bonus’injectionafterresolutionofCNVactivity.Duringfollow-up,eyesweremonitoredwithfluoresceinangiography,opticalcoherencetomography,andbest-correctedvisualacuity(BCVA).IncaseofrecurrencesofCNVactivity,eyeswereretreatedwithotherroundsofbevacizumabinjectionsfollowingthesametreatmentprotocol.RESULTS:Overamedianfollow-upof532d,themedianresolutiontimeofCNVactivityinthefirst,second,andthirdtreatmentroundwas98d,126d,and111d,respectively.Themedianrecurrencetimeforthethreeroundswas154d,126d,and151d,respectively.Nosignificantdifferenceinresolutiontime(P=0.09)orinrecurrencetime(P=0.11)wasdetectedamongtreatmentrounds.Age(P=0.0082)andlensstatus(P=0.035)werefoundtobeassociatedwithCNVresolution;forevery1-yearincreaseinagetherewas4%greaterchanceofCNVresolution;Phakiceyesdemonstrateda33%betterchancetoexperienceCNVresolutionthanpseudophakiceyes.ForCNVrecurrence,lensstatus(P=0.0009)andgender(P=0.0446)werefoundtobepredictive;pseudophakiceyeshada3.69-foldgreaterrisktoexperiencerecurrenceofCNVactivitycomparedtophakiceyes;maleshada2.19-foldgreaterrisktoexperiencerecurrenceofCNVactivitythanfemales.NosignificantBCVAchangesamongthreetreatmentroundswerenoted(P=0.56).CONCLUSION:ResolutiontimeandrecurrencetimeofCNVactivitywerenotsignificantlydifferentamongtreatmentrounds,suggestingabsenceoftachyphylaxistobevacizumab.Acautiousdecisionshouldbemadeupondisco