摘要
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused many deaths and contributed to a tremendous public health concern worldwide since 2020. Angiotensin-converting enzyme 2 (ACE2) binds to the SARS-CoV-2 virus as a receptor. The challenge of different nonhuman primate (NHP) species by SARS-CoV-2 virus demonstrated different effects on virus replication and disease pathology. This study characterizes differences between host ACE2 sequences of three NHP species: Macaca mulatta, Macaca fascicularis, and Chlorocebus sabaeus. In addition, the binding affinity between the ACE2 ectodomain and the SARS-CoV-2 S receptor-binding domain (RBD) was analyzed. Variation of ACE2 sequence among NHP species and the binding affinity may account for different susceptibility and responses to SARS-CoV-2 infection.
机构地区
Department of Biosafety, China Biotechnology Co.LTD, Beijing 100025, China,Department of Infectious Diseases, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China,Laboratory Animal Center, Academy of Military Medical Sciences, Beijing 100071, China
出版日期
2022年12月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
