摘要
Thereareseveralchallengestoinnereardrugdeliveryandimagingduetotheexistenceoftightbiologicalbarrierstothetargetstructureandthedensebonesurroundingit.Advancesinimagingandnanomedicinemayprovideknowledgeforovercomingtheexistinglimitationstoboththediagnosisandtreatmentofinnereardiseases.Noveltechniqueshaveimprovedtheefficacyofdrugdeliveryandtargetingtotheinnerear,aswellasthequalityandaccuracyofimagingthisstructure.Inthisreview,wewilldescribethepathwaysandbiologicalbarriersoftheinnerearregardingdrugdelivery,thebeneficialapplicationsandlimitationsoftheimagingtechniquesavailableforinnerearresearch,thebehaviorofengineerednanomaterialsininnerearapplications,andfutureperspectivesfornanomedicine-basedinnerearimaging.
出版日期
2016年04月14日(中国期刊网平台首次上网日期,不代表论文的发表时间)