A novel α-fetoprotein-MIP immunosensor based on AuNPs/PTh modified glass carbon electrode

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摘要 Anewα-fetoprotein-MIP(AFP-MIP)immunosensorbasedonglasscarbonelectrode(GCE)modifiedwithpolythionine(PTh)andgoldnanoparticles(AuNPs)wassuccessfullyfabricatedforsensitivedetectionofα-fetoprotein(AFP).Throughcontrollingelectropolymerization,A“polydopamine(PDA)-AFP”complexwasachievedapplyingAFPastemplateanddopamine(DA)asimprintedmonomers.Afterelution,thespecificcavitiescanadsorbthetargetmolecules.Usingdifferentialpulsevoltammetry(DPV)detection,thepeakcurrentdecreasedwiththeincreaseinconcentrationofAFP,andthelinearresponserangeoftheAFP-MIPimmunosensorwasfrom0.001ng/mLto800ng/mLwiththedetectionlimitaslowas0.8138pg/mL.TheMIPimmunosensorcouldbecomeanewpromisingmethodforthedetectionofAFP.Furthermore,thisMIPsensorwasdemonstratedintestingAFPinhumanserumsampleswithsatisfactoryresults.
机构地区 不详
出版日期 2019年01月11日(中国期刊网平台首次上网日期,不代表论文的发表时间)
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